CACNA2D1

calcium voltage-gated channel auxiliary subunit alpha2delta 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
calcium ion transport [GO:0006816],
regulation of calcium ion transport [GO:0051924],
regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307],
calcium ion transport into cytosol [GO:0060402],
cardiac conduction [GO:0061337],
calcium ion transmembrane transport via high voltage-gated calcium channel [GO:0061577],
cardiac muscle cell action potential involved in contraction [GO:0086002],
membrane depolarization during bundle of His cell action potential [GO:0086048],
regulation of heart rate by cardiac conduction [GO:0086091],
calcium ion import across plasma membrane [GO:0098703],
regulation of membrane repolarization during action potential [GO:0098903],
positive regulation of high voltage-gated calcium channel activity [GO:1901843],
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514],
cellular response to beta-amyloid [GO:1904646],
ion transport [GO:0006811],
regulation of ion transmembrane transport [GO:0034765],
calcium ion transmembrane transport [GO:0070588],
positive regulation of voltage-gated calcium channel activity [GO:1901387],

Molecular Function:
voltage-gated calcium channel activity [GO:0005245],
metal ion binding [GO:0046872],
voltage-gated calcium channel activity involved in cardiac muscle cell action potential [GO:0086007],
voltage-gated calcium channel activity involved in bundle of His cell action potential [GO:0086057],
voltage-gated ion channel activity [GO:0005244],
calcium channel activity [GO:0005262],
protein binding [GO:0005515],

Cellular Component:
plasma membrane [GO:0005886],
voltage-gated calcium channel complex [GO:0005891],
sarcoplasmic reticulum [GO:0016529],
extracellular exosome [GO:0070062],
L-type voltage-gated calcium channel complex [GO:1990454],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
T-tubule [GO:0030315],
glutamatergic synapse [GO:0098978],
anchored component of postsynaptic membrane [GO:0099025],
anchored component of presynaptic active zone membrane [GO:0099029],