CACNA1D

calcium voltage-gated channel subunit alpha1 D

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2, Li-Fraumeni Human YES

GO terms:

Biological Process:
calcium ion transport [GO:0006816],
adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188],
sensory perception of sound [GO:0007605],
positive regulation of adenylate cyclase activity [GO:0045762],
regulation of insulin secretion [GO:0050796],
positive regulation of calcium ion transport [GO:0051928],
regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372],
cardiac conduction [GO:0061337],
calcium ion import [GO:0070509],
calcium ion transmembrane transport [GO:0070588],
cardiac muscle cell action potential involved in contraction [GO:0086002],
membrane depolarization during cardiac muscle cell action potential [GO:0086012],
membrane depolarization during SA node cell action potential [GO:0086046],
regulation of heart rate by cardiac conduction [GO:0086091],
induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration [GO:0099703],
regulation of potassium ion transmembrane transporter activity [GO:1901016],
regulation of potassium ion transmembrane transport [GO:1901379],
ion transport [GO:0006811],
calcium-mediated signaling [GO:0019722],
positive regulation of CREB transcription factor activity [GO:0032793],
regulation of ion transmembrane transport [GO:0034765],
positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774],
regulation of calcium ion transport [GO:0051924],
transmembrane transport [GO:0055085],
divalent metal ion transport [GO:0070838],
positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904879],

Molecular Function:
voltage-gated calcium channel activity [GO:0005245],
calcium channel activity [GO:0005262],
high voltage-gated calcium channel activity [GO:0008331],
ankyrin binding [GO:0030506],
metal ion binding [GO:0046872],
alpha-actinin binding [GO:0051393],
voltage-gated calcium channel activity involved in cardiac muscle cell action potential [GO:0086007],
voltage-gated calcium channel activity involved SA node cell action potential [GO:0086059],
voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels [GO:0099635],
ion channel activity [GO:0005216],
voltage-gated ion channel activity [GO:0005244],
protein binding [GO:0005515],
PDZ domain binding [GO:0030165],

Cellular Component:
plasma membrane [GO:0005886],
voltage-gated calcium channel complex [GO:0005891],
Z disc [GO:0030018],
integral component of presynaptic active zone membrane [GO:0099059],
L-type voltage-gated calcium channel complex [GO:1990454],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
integral component of plasma membrane [GO:0005887],
cell surface [GO:0009986],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
apical plasma membrane [GO:0016324],
dendrite [GO:0030425],
dendrite membrane [GO:0032590],
sarcolemma [GO:0042383],
neuronal cell body [GO:0043025],