CACNA1C

calcium voltage-gated channel subunit alpha1 C

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2, Li-Fraumeni Human YES

GO terms:

Biological Process:
immune system development [GO:0002520],
calcium ion transport [GO:0006816],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
heart development [GO:0007507],
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881],
embryonic forelimb morphogenesis [GO:0035115],
calcium-mediated signaling using extracellular calcium source [GO:0035585],
camera-type eye development [GO:0043010],
positive regulation of adenylate cyclase activity [GO:0045762],
regulation of insulin secretion [GO:0050796],
calcium ion transport into cytosol [GO:0060402],
cardiac conduction [GO:0061337],
calcium ion transmembrane transport via high voltage-gated calcium channel [GO:0061577],
calcium ion import [GO:0070509],
calcium ion transmembrane transport [GO:0070588],
cardiac muscle cell action potential involved in contraction [GO:0086002],
membrane depolarization during cardiac muscle cell action potential [GO:0086012],
membrane depolarization during AV node cell action potential [GO:0086045],
cell communication by electrical coupling involved in cardiac conduction [GO:0086064],
regulation of heart rate by cardiac conduction [GO:0086091],
regulation of ventricular cardiac muscle cell action potential [GO:0098911],
membrane depolarization during atrial cardiac muscle cell action potential [GO:0098912],
ion transport [GO:0006811],
cellular calcium ion homeostasis [GO:0006874],
smooth muscle contraction [GO:0006939],
chemical synaptic transmission [GO:0007268],
adult walking behavior [GO:0007628],
regulation of blood pressure [GO:0008217],
visual learning [GO:0008542],
calcium ion regulated exocytosis [GO:0017156],
regulation of vasoconstriction [GO:0019229],
insulin secretion [GO:0030073],
growth hormone secretion [GO:0030252],
regulation of ion transmembrane transport [GO:0034765],
glucose homeostasis [GO:0042593],
regulation of organ growth [GO:0046620],
transmembrane transport [GO:0055085],
smooth muscle contraction involved in micturition [GO:0060083],
positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904879],

Molecular Function:
voltage-gated calcium channel activity [GO:0005245],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
high voltage-gated calcium channel activity [GO:0008331],
metal ion binding [GO:0046872],
alpha-actinin binding [GO:0051393],
voltage-gated calcium channel activity involved in cardiac muscle cell action potential [GO:0086007],
voltage-gated calcium channel activity involved in AV node cell action potential [GO:0086056],
ion channel activity [GO:0005216],
voltage-gated ion channel activity [GO:0005244],
calcium channel activity [GO:0005262],
enzyme binding [GO:0019899],
protein domain specific binding [GO:0019904],
translation initiation factor binding [GO:0031369],
ion channel binding [GO:0044325],
protein phosphatase 2A binding [GO:0051721],
voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential [GO:1905030],

Cellular Component:
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
voltage-gated calcium channel complex [GO:0005891],
postsynaptic density [GO:0014069],
integral component of membrane [GO:0016021],
Z disc [GO:0030018],
cell junction [GO:0030054],
dendrite [GO:0030425],
perikaryon [GO:0043204],
postsynaptic membrane [GO:0045211],
L-type voltage-gated calcium channel complex [GO:1990454],
caveolar macromolecular signaling complex [GO:0002095],
cell surface [GO:0009986],
membrane [GO:0016020],
T-tubule [GO:0030315],
macromolecular complex [GO:0032991],
sarcolemma [GO:0042383],
presynaptic membrane [GO:0042734],
cell projection [GO:0042995],
neuronal cell body [GO:0043025],
dendritic shaft [GO:0043198],
synapse [GO:0045202],
glutamatergic synapse [GO:0098978],
integral component of postsynaptic membrane [GO:0099055],
integral component of presynaptic membrane [GO:0099056],