CACNA1A

calcium voltage-gated channel subunit alpha1 A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
calcium ion transport [GO:0006816],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
chemical synaptic transmission [GO:0007268],
cell death [GO:0008219],
regulation of ion transmembrane transport [GO:0034765],
regulation of insulin secretion [GO:0050796],
modulation of synaptic transmission [GO:0050804],
membrane depolarization [GO:0051899],
calcium ion import [GO:0070509],
calcium ion transmembrane transport [GO:0070588],
response to beta-amyloid [GO:1904645],
cellular response to beta-amyloid [GO:1904646],
regulation of neurotransmitter levels [GO:0001505],
ion transport [GO:0006811],
gamma-aminobutyric acid signaling pathway [GO:0007214],
neuron-neuron synaptic transmission [GO:0007270],
neuromuscular synaptic transmission [GO:0007274],
synapse assembly [GO:0007416],
adult walking behavior [GO:0007628],
regulation of hormone levels [GO:0010817],
gamma-aminobutyric acid secretion [GO:0014051],
regulation of acetylcholine secretion, neurotransmission [GO:0014056],
calcium ion regulated exocytosis [GO:0017156],
regulation of calcium ion-dependent exocytosis [GO:0017158],
transmission of nerve impulse [GO:0019226],
sensory perception of pain [GO:0019233],
spinal cord motor neuron differentiation [GO:0021522],
cerebellum maturation [GO:0021590],
cerebellar molecular layer development [GO:0021679],
cerebellar Purkinje cell layer development [GO:0021680],
cerebellar Purkinje cell differentiation [GO:0021702],
vestibular nucleus development [GO:0021750],
central nervous system neuron differentiation [GO:0021953],
cellular chloride ion homeostasis [GO:0030644],
regulation of sulfur amino acid metabolic process [GO:0031335],
negative regulation of hormone biosynthetic process [GO:0032353],
synaptic transmission, glutamatergic [GO:0035249],
regulation of membrane potential [GO:0042391],
glucose homeostasis [GO:0042593],
receptor clustering [GO:0043113],
negative regulation of neuron apoptotic process [GO:0043524],
response to pain [GO:0048265],
behavioral response to pain [GO:0048266],
calcium ion-regulated exocytosis of neurotransmitter [GO:0048791],
dendrite morphogenesis [GO:0048813],
regulation of axonogenesis [GO:0050770],
neurological system process [GO:0050877],
musculoskeletal movement, spinal reflex action [GO:0050883],
neuromuscular process controlling balance [GO:0050885],
neuromuscular process [GO:0050905],
synaptic transmission, GABAergic [GO:0051932],
transmembrane transport [GO:0055085],
rhythmic synaptic transmission [GO:0060024],
regulation of voltage-gated calcium channel activity [GO:1901385],

Molecular Function:
beta-amyloid binding [GO:0001540],
voltage-gated calcium channel activity [GO:0005245],
protein binding [GO:0005515],
high voltage-gated calcium channel activity [GO:0008331],
syntaxin binding [GO:0019905],
metal ion binding [GO:0046872],
ion channel activity [GO:0005216],
voltage-gated ion channel activity [GO:0005244],
calcium channel activity [GO:0005262],
calmodulin binding [GO:0005516],
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium ion concentration [GO:0099626],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
voltage-gated calcium channel complex [GO:0005891],
integral component of membrane [GO:0016021],
cell projection [GO:0042995],
neuronal cell body [GO:0043025],
membrane [GO:0016020],
dendrite [GO:0030425],
macromolecular complex [GO:0032991],
perikaryon [GO:0043204],
glutamatergic synapse [GO:0098978],
integral component of presynaptic active zone membrane [GO:0099059],