C5AR1

complement C5a receptor 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
activation of MAPK activity [GO:0000187],
complement receptor mediated signaling pathway [GO:0002430],
apoptotic process [GO:0006915],
chemotaxis [GO:0006935],
inflammatory response [GO:0006954],
immune response [GO:0006955],
cellular defense response [GO:0006968],
signal transduction [GO:0007165],
G-protein coupled receptor signaling pathway [GO:0007186],
phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200],
activation of phospholipase C activity [GO:0007202],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
sensory perception of chemical stimulus [GO:0007606],
positive regulation of vascular endothelial growth factor production [GO:0010575],
positive regulation of macrophage chemotaxis [GO:0010759],
cell proliferation in hindbrain [GO:0021534],
regulation of complement activation [GO:0030449],
neutrophil chemotaxis [GO:0030593],
animal organ regeneration [GO:0031100],
response to peptidoglycan [GO:0032494],
response to lipopolysaccharide [GO:0032496],
complement component C5a signaling pathway [GO:0038178],
mRNA transcription from RNA polymerase II promoter [GO:0042789],
neutrophil degranulation [GO:0043312],
negative regulation of neuron apoptotic process [GO:0043524],
positive regulation of angiogenesis [GO:0045766],
positive regulation of epithelial cell proliferation [GO:0050679],
defense response to Gram-positive bacterium [GO:0050830],
cognition [GO:0050890],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
positive regulation of neutrophil chemotaxis [GO:0090023],
regulation of beta-amyloid clearance [GO:1900221],
regulation of tau-protein kinase activity [GO:1902947],
regulation of microglial cell activation [GO:1903978],

Molecular Function:
complement component C5a binding [GO:0001856],
complement component C5a receptor activity [GO:0004878],
G-protein coupled receptor activity [GO:0004930],
complement receptor activity [GO:0004875],

Cellular Component:
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell surface [GO:0009986],
basolateral plasma membrane [GO:0016323],
secretory granule membrane [GO:0030667],
apical part of cell [GO:0045177],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
cytoplasmic vesicle [GO:0031410],