C3AR1

complement C3a receptor 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
complement receptor mediated signaling pathway [GO:0002430],
chemotaxis [GO:0006935],
inflammatory response [GO:0006954],
G-protein coupled receptor signaling pathway [GO:0007186],
phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
blood circulation [GO:0008015],
positive regulation of vascular endothelial growth factor production [GO:0010575],
positive regulation of macrophage chemotaxis [GO:0010759],
regulation of complement activation [GO:0030449],
neutrophil degranulation [GO:0043312],
positive regulation of angiogenesis [GO:0045766],
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482],
positive regulation of neutrophil chemotaxis [GO:0090023],
tolerance induction to nonself antigen [GO:0002462],
signal transduction [GO:0007165],
regulation of blood pressure [GO:0008217],
positive regulation of cell migration [GO:0030335],
positive regulation of smooth muscle cell proliferation [GO:0048661],
positive regulation of glomerular mesangial cell proliferation [GO:0072126],
positive regulation of DNA biosynthetic process [GO:2000573],

Molecular Function:
complement component C3a receptor activity [GO:0004876],
G-protein coupled receptor activity [GO:0004930],
complement component C3a binding [GO:0001850],
complement receptor activity [GO:0004875],

Cellular Component:
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
azurophil granule membrane [GO:0035577],
specific granule membrane [GO:0035579],
membrane [GO:0016020],
integral component of membrane [GO:0016021],