complement C3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
positive regulation of type IIa hypersensitivity [GO:0001798],
positive regulation of protein phosphorylation [GO:0001934],
positive regulation of activation of membrane attack complex [GO:0001970],
fatty acid metabolic process [GO:0006631],
inflammatory response [GO:0006954],
immune response [GO:0006955],
complement activation [GO:0006956],
complement activation, alternative pathway [GO:0006957],
complement activation, classical pathway [GO:0006958],
signal transduction [GO:0007165],
G-protein coupled receptor signaling pathway [GO:0007186],
response to bacterium [GO:0009617],
positive regulation of vascular endothelial growth factor production [GO:0010575],
positive regulation of glucose transport [GO:0010828],
regulation of triglyceride biosynthetic process [GO:0010866],
positive regulation of lipid storage [GO:0010884],
negative regulation of endopeptidase activity [GO:0010951],
neuron remodeling [GO:0016322],
regulation of complement activation [GO:0030449],
neutrophil degranulation [GO:0043312],
post-translational protein modification [GO:0043687],
cellular protein metabolic process [GO:0044267],
positive regulation of G-protein coupled receptor protein signaling pathway [GO:0045745],
positive regulation of angiogenesis [GO:0045766],
positive regulation of receptor-mediated endocytosis [GO:0048260],
regulation of immune response [GO:0050776],
positive regulation of phagocytosis, engulfment [GO:0060100],
beta-amyloid clearance [GO:0097242],
cell surface receptor signaling pathway involved in cell-cell signaling [GO:1905114],
positive regulation of apoptotic cell clearance [GO:2000427],
immune system process [GO:0002376],
lipid metabolic process [GO:0006629],
blood coagulation [GO:0007596],
innate immune response [GO:0045087],
positive regulation of developmental growth [GO:0048639],
positive regulation of phagocytosis [GO:0050766],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
complement-dependent cytotoxicity [GO:0097278],

Molecular Function:
endopeptidase inhibitor activity [GO:0004866],
receptor binding [GO:0005102],
protein binding [GO:0005515],
C5L2 anaphylatoxin chemotactic receptor binding [GO:0031715],
lipid binding [GO:0008289],
cofactor binding [GO:0048037],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
endoplasmic reticulum lumen [GO:0005788],
plasma membrane [GO:0005886],
macromolecular complex [GO:0032991],
secretory granule lumen [GO:0034774],
azurophil granule lumen [GO:0035578],
extracellular exosome [GO:0070062],
blood microparticle [GO:0072562],
cell surface [GO:0009986],