complement C1r

Link to human ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2, Li-Fraumeni Human YES

GO terms:

Biological Process:
immune response [GO:0006955],
complement activation [GO:0006956],
complement activation, classical pathway [GO:0006958],
regulation of complement activation [GO:0030449],
zymogen activation [GO:0031638],
innate immune response [GO:0045087],

Molecular Function:
serine-type endopeptidase activity [GO:0004252],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
serine-type peptidase activity [GO:0008236],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
extracellular exosome [GO:0070062],
blood microparticle [GO:0072562],