complement C1q binding protein

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2, Li-Fraumeni Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
mRNA processing [GO:0006397],
apoptotic process [GO:0006915],
immune response [GO:0006955],
complement activation, classical pathway [GO:0006958],
blood coagulation, intrinsic pathway [GO:0007597],
RNA splicing [GO:0008380],
phosphatidylinositol 3-kinase signaling [GO:0014065],
viral process [GO:0016032],
regulation of complement activation [GO:0030449],
negative regulation of interferon-gamma production [GO:0032689],
negative regulation of interleukin-12 production [GO:0032695],
negative regulation of MDA-5 signaling pathway [GO:0039534],
negative regulation of RIG-I signaling pathway [GO:0039536],
mature ribosome assembly [GO:0042256],
positive regulation of apoptotic process [GO:0043065],
innate immune response [GO:0045087],
positive regulation of cell adhesion [GO:0045785],
negative regulation of mRNA splicing, via spliceosome [GO:0048025],
negative regulation of defense response to virus [GO:0050687],
positive regulation of protein kinase B signaling [GO:0051897],
positive regulation of mitochondrial translation [GO:0070131],
positive regulation of neutrophil chemotaxis [GO:0090023],
positive regulation of substrate adhesion-dependent cell spreading [GO:1900026],
positive regulation of trophoblast cell migration [GO:1901165],
positive regulation of dendritic cell chemotaxis [GO:2000510],
adaptive immune response [GO:0002250],
immune system process [GO:0002376],
ribosome biogenesis [GO:0042254],

Molecular Function:
complement component C1q binding [GO:0001849],
transcription corepressor activity [GO:0003714],
mRNA binding [GO:0003729],
protein kinase C binding [GO:0005080],
protein binding [GO:0005515],
hyaluronic acid binding [GO:0005540],
transcription factor binding [GO:0008134],
translation activator activity [GO:0008494],
kininogen binding [GO:0030984],
adrenergic receptor binding [GO:0031690],
mitochondrial ribosome binding [GO:0097177],

Cellular Component:
extracellular space [GO:0005615],
nucleus [GO:0005634],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
mitochondrial matrix [GO:0005759],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
membrane [GO:0016020],
presynaptic active zone [GO:0048786],
glutamatergic synapse [GO:0098978],
GABA-ergic synapse [GO:0098982],
extracellular region [GO:0005576],
presynapse [GO:0098793],