BUD23

BUD23 rRNA methyltransferase and ribosome maturation factor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA23 Skin, Lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
chromatin organization [GO:0006325],
rRNA processing [GO:0006364],
methylation [GO:0032259],
ribosome biogenesis [GO:0042254],
rRNA (guanine-N7)-methylation [GO:0070476],
positive regulation of rRNA processing [GO:2000234],
rRNA methylation [GO:0031167],

Molecular Function:
methyltransferase activity [GO:0008168],
rRNA (guanine) methyltransferase activity [GO:0016435],
transferase activity [GO:0016740],
protein heterodimerization activity [GO:0046982],
RNA binding [GO:0003723],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
perinuclear region of cytoplasm [GO:0048471],