VPS18

VPS18 core subunit of CORVET and HOPS complexes

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA418 Skin, Lung Human YES

GO terms:

Biological Process:
intracellular protein transport [GO:0006886],
vesicle docking involved in exocytosis [GO:0006904],
autophagy [GO:0006914],
endosome organization [GO:0007032],
vacuole organization [GO:0007033],
lysosome organization [GO:0007040],
endosome to lysosome transport [GO:0008333],
regulation of SNARE complex assembly [GO:0035542],
viral entry into host cell [GO:0046718],
regulation of synaptic vesicle exocytosis [GO:2000300],
protein transport [GO:0015031],
vesicle-mediated transport [GO:0016192],

Molecular Function:
actin binding [GO:0003779],
protein binding [GO:0005515],
syntaxin binding [GO:0019905],
protein binding, bridging [GO:0030674],
metal ion binding [GO:0046872],

Cellular Component:
lysosome [GO:0005764],
lysosomal membrane [GO:0005765],
endosome [GO:0005768],
early endosome [GO:0005769],
late endosome [GO:0005770],
autophagosome [GO:0005776],
actin filament [GO:0005884],
AP-3 adaptor complex [GO:0030123],
clathrin-coated vesicle [GO:0030136],
HOPS complex [GO:0030897],
late endosome membrane [GO:0031902],
CORVET complex [GO:0033263],
presynapse [GO:0098793],
glutamatergic synapse [GO:0098978],
membrane [GO:0016020],
cytoplasmic vesicle [GO:0031410],