BUB1

BUB1 mitotic checkpoint serine/threonine kinase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
17488820 HEK 293T, WI-38, IMR-90 Human NO
23448364 MEF Thymus Mouse NO
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
27731420 IMR-90 Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2, Li-Fraumeni Human YES
30987592 MCF7 Breast Human YES

GO terms:

Biological Process:
protein phosphorylation [GO:0006468],
apoptotic process [GO:0006915],
regulation of sister chromatid cohesion [GO:0007063],
mitotic cell cycle checkpoint [GO:0007093],
mitotic spindle assembly checkpoint [GO:0007094],
cell proliferation [GO:0008283],
viral process [GO:0016032],
cell division [GO:0051301],
meiotic sister chromatid cohesion, centromeric [GO:0051754],
regulation of chromosome segregation [GO:0051983],
cell cycle [GO:0007049],
chromosome segregation [GO:0007059],
phosphorylation [GO:0016310],
positive regulation of intrinsic apoptotic signaling pathway [GO:2001244],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
protein binding [GO:0005515],
ATP binding [GO:0005524],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
kinetochore [GO:0000776],
condensed chromosome kinetochore [GO:0000777],
condensed nuclear chromosome kinetochore [GO:0000778],
condensed nuclear chromosome outer kinetochore [GO:0000942],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
membrane [GO:0016020],
chromosome, centromeric region [GO:0000775],
condensed nuclear chromosome, centromeric region [GO:0000780],
nucleus [GO:0005634],
chromosome [GO:0005694],