beta-transducin repeat containing E3 ubiquitin protein ligase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

GO terms:

Biological Process:
G2/M transition of mitotic cell cycle [GO:0000086],
protein polyubiquitination [GO:0000209],
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462],
stimulatory C-type lectin receptor signaling pathway [GO:0002223],
protein dephosphorylation [GO:0006470],
ubiquitin-dependent protein catabolic process [GO:0006511],
signal transduction [GO:0007165],
viral process [GO:0016032],
Wnt signaling pathway [GO:0016055],
protein ubiquitination [GO:0016567],
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146],
protein destabilization [GO:0031648],
mammary gland epithelial cell proliferation [GO:0033598],
NIK/NF-kappaB signaling [GO:0038061],
Fc-epsilon receptor signaling pathway [GO:0038095],
regulation of circadian rhythm [GO:0042752],
positive regulation of circadian rhythm [GO:0042753],
regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122],
proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161],
negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433],
post-translational protein modification [GO:0043687],
positive regulation of proteolysis [GO:0045862],
negative regulation of smoothened signaling pathway [GO:0045879],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
rhythmic process [GO:0048511],
T cell receptor signaling pathway [GO:0050852],
stress-activated MAPK cascade [GO:0051403],
branching involved in mammary gland duct morphogenesis [GO:0060444],
regulation of canonical Wnt signaling pathway [GO:0060828],
regulation of proteasomal protein catabolic process [GO:0061136],
interleukin-1-mediated signaling pathway [GO:0070498],
cellular response to organic cyclic compound [GO:0071407],
regulation of mitotic cell cycle phase transition [GO:1901990],
protein catabolic process [GO:0030163],
regulation of cell cycle [GO:0051726],

Molecular Function:
ubiquitin-protein transferase activity [GO:0004842],
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
ligase activity [GO:0016874],
protein phosphorylated amino acid binding [GO:0045309],
protein dimerization activity [GO:0046983],
ubiquitin protein ligase activity [GO:0061630],

Cellular Component:
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
SCF ubiquitin ligase complex [GO:0019005],
small-subunit processome [GO:0032040],
Pwp2p-containing subcomplex of 90S preribosome [GO:0034388],
nucleus [GO:0005634],
cytoplasm [GO:0005737],