BTK

Bruton tyrosine kinase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
25412306 EJ Human NO
27630139 HCT116, HT-18, EJ Human NO
29290977 HCT116, HT-18 Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28915637 H929, OCI-My5, OPM-2, MEF Human, mouse NO

GO terms:

Biological Process:
positive regulation of type III hypersensitivity [GO:0001805],
positive regulation of type I hypersensitivity [GO:0001812],
negative regulation of cytokine production [GO:0001818],
adaptive immune response [GO:0002250],
B cell affinity maturation [GO:0002344],
histamine secretion by mast cell [GO:0002553],
regulation of B cell cytokine production [GO:0002721],
MyD88-dependent toll-like receptor signaling pathway [GO:0002755],
regulation of B cell apoptotic process [GO:0002902],
protein phosphorylation [GO:0006468],
G-protein coupled receptor signaling pathway [GO:0007186],
I-kappaB kinase/NF-kappaB signaling [GO:0007249],
mesoderm development [GO:0007498],
peptidyl-tyrosine phosphorylation [GO:0018108],
calcium-mediated signaling [GO:0019722],
negative regulation of B cell proliferation [GO:0030889],
cellular response to reactive oxygen species [GO:0034614],
intracellular signal transduction [GO:0035556],
peptidyl-tyrosine autophosphorylation [GO:0038083],
Fc-epsilon receptor signaling pathway [GO:0038095],
B cell activation [GO:0042113],
innate immune response [GO:0045087],
positive regulation of B cell differentiation [GO:0045579],
cell maturation [GO:0048469],
T cell receptor signaling pathway [GO:0050852],
B cell receptor signaling pathway [GO:0050853],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
cellular response to molecule of fungal origin [GO:0071226],
apoptotic signaling pathway [GO:0097190],
cellular response to interleukin-7 [GO:0098761],
immune system process [GO:0002376],
apoptotic process [GO:0006915],
response to organic substance [GO:0010033],
phosphorylation [GO:0016310],
protein autophosphorylation [GO:0046777],

Molecular Function:
protein tyrosine kinase activity [GO:0004713],
non-membrane spanning protein tyrosine kinase activity [GO:0004715],
protein binding [GO:0005515],
ATP binding [GO:0005524],
phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547],
identical protein binding [GO:0042802],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
lipid binding [GO:0008289],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cytoplasmic vesicle [GO:0031410],
mast cell granule [GO:0042629],
membrane raft [GO:0045121],
perinuclear region of cytoplasm [GO:0048471],
membrane [GO:0016020],