BRSK1

BR serine/threonine kinase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA267 Skin, Lung Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
protein phosphorylation [GO:0006468],
cellular response to DNA damage stimulus [GO:0006974],
mitotic G2 DNA damage checkpoint [GO:0007095],
neurotransmitter secretion [GO:0007269],
axonogenesis [GO:0007409],
associative learning [GO:0008306],
response to UV [GO:0009411],
response to ionizing radiation [GO:0010212],
regulation of neuron projection development [GO:0010975],
establishment of cell polarity [GO:0030010],
neuron differentiation [GO:0030182],
intracellular signal transduction [GO:0035556],
regulation of synaptic plasticity [GO:0048167],
regulation of axonogenesis [GO:0050770],
centrosome duplication [GO:0051298],
microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176],
synaptic vesicle cycle [GO:0099504],
regulation of synaptic vesicle clustering [GO:2000807],
G2/M transition of mitotic cell cycle [GO:0000086],
cell cycle [GO:0007049],
nervous system development [GO:0007399],
phosphorylation [GO:0016310],
peptidyl-serine phosphorylation [GO:0018105],
neuron projection morphogenesis [GO:0048812],

Molecular Function:
magnesium ion binding [GO:0000287],
protein serine/threonine kinase activity [GO:0004674],
ATP binding [GO:0005524],
protein kinase binding [GO:0019901],
gamma-tubulin binding [GO:0043015],
tau protein binding [GO:0048156],
tau-protein kinase activity [GO:0050321],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
protein binding [GO:0005515],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
centrosome [GO:0005813],
synaptic vesicle [GO:0008021],
cell junction [GO:0030054],
presynaptic active zone [GO:0048786],
cytoskeleton [GO:0005856],
synapse [GO:0045202],