BRD4

bromodomain containing 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27099234 IMR-90, WI-38, BJ, Primary macrophages derived from blood , Natural killer cells, Phoenix cells Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27624132 W12 Human NO
29434197 AGS, AZ521, NCI-N87, MKN28, MNK45, SGC-791, SNU-5, SNU-16 Stomach human NO

GO terms:

Biological Process:
regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083],
chromatin organization [GO:0006325],
protein phosphorylation [GO:0006468],
cellular response to DNA damage stimulus [GO:0006974],
positive regulation of G2/M transition of mitotic cell cycle [GO:0010971],
viral process [GO:0016032],
positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
regulation of inflammatory response [GO:0050727],
regulation of phosphorylation of RNA polymerase II C-terminal domain [GO:1901407],
positive regulation of histone H3-K36 trimethylation [GO:2001255],
inner cell mass cell proliferation [GO:0001833],
chromosome segregation [GO:0007059],
positive regulation of DNA binding [GO:0043388],
histone H4-K12 acetylation [GO:0043983],
histone H3-K14 acetylation [GO:0044154],
protein autophosphorylation [GO:0046777],

Molecular Function:
transcription factor activity, transcription factor recruiting [GO:0001134],
p53 binding [GO:0002039],
chromatin binding [GO:0003682],
protein binding [GO:0005515],
RNA polymerase II carboxy-terminal domain kinase activity [GO:0008353],
enzyme binding [GO:0019899],
lysine-acetylated histone binding [GO:0070577],
DNA binding [GO:0003677],
GTP-dependent protein kinase activity [GO:0034211],

Cellular Component:
condensed nuclear chromosome [GO:0000794],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
nuclear chromatin [GO:0000790],
chromosome [GO:0005694],
nucleolus [GO:0005730],
cyclin/CDK positive transcription elongation factor complex [GO:0008024],