BRCA2

BRCA2 DNA repair associated

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES
30008586 BMSCs Human NO

GO terms:

Biological Process:
mitotic cytokinesis [GO:0000281],
telomere maintenance via recombination [GO:0000722],
double-strand break repair via homologous recombination [GO:0000724],
oocyte maturation [GO:0001556],
inner cell mass cell proliferation [GO:0001833],
nucleotide-excision repair [GO:0006289],
double-strand break repair [GO:0006302],
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978],
male meiosis I [GO:0007141],
spermatogenesis [GO:0007283],
brain development [GO:0007420],
cell aging [GO:0007569],
female gonad development [GO:0008585],
response to X-ray [GO:0010165],
response to UV-C [GO:0010225],
response to gamma radiation [GO:0010332],
hemopoiesis [GO:0030097],
regulation of cytokinesis [GO:0032465],
negative regulation of mammary gland epithelial cell proliferation [GO:0033600],
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771],
histone H3 acetylation [GO:0043966],
histone H4 acetylation [GO:0043967],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of mitotic cell cycle [GO:0045931],
replication fork protection [GO:0048478],
centrosome duplication [GO:0051298],
establishment of protein localization to telomere [GO:0070200],
mitotic recombination-dependent replication fork processing [GO:1990426],
DNA repair [GO:0006281],
DNA recombination [GO:0006310],
cellular response to DNA damage stimulus [GO:0006974],
cell cycle [GO:0007049],
cell proliferation [GO:0008283],
intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630],
mammary gland development [GO:0030879],
homologous chromosome orientation involved in meiotic metaphase I plate congression [GO:0031619],
multicellular organism growth [GO:0035264],
chordate embryonic development [GO:0043009],
chromosome organization [GO:0051276],

Molecular Function:
protease binding [GO:0002020],
single-stranded DNA binding [GO:0003697],
histone acetyltransferase activity [GO:0004402],
protein binding [GO:0005515],
protein C-terminus binding [GO:0008022],
H3 histone acetyltransferase activity [GO:0010484],
H4 histone acetyltransferase activity [GO:0010485],
identical protein binding [GO:0042802],
gamma-tubulin binding [GO:0043015],
DNA binding [GO:0003677],

Cellular Component:
nuclear chromosome, telomeric region [GO:0000784],
lateral element [GO:0000800],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
centrosome [GO:0005813],
cytosol [GO:0005829],
secretory granule [GO:0030141],
macromolecular complex [GO:0032991],
BRCA2-MAGE-D1 complex [GO:0033593],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],