BRCA1

BRCA1 DNA repair associated

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
19559722 U2OS, A549 Human NO
21678067 C-85 Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
12533509 MEF Mouse NO
19372557 HBL1, MCF7, T47D Human NO
23438604 IMR-90 Human NO
26106036 HMECs Breast Human NO
27811360 Primary epithelial cells derived from mammary gland Breast Mouse NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
29449545 HMECs, MRC5, IMR-90, GP293, WI-38, HUVEC Human NO

GO terms:

Biological Process:
double-strand break repair via homologous recombination [GO:0000724],
DNA double-strand break processing [GO:0000729],
DNA replication [GO:0006260],
postreplication repair [GO:0006301],
double-strand break repair [GO:0006302],
double-strand break repair via nonhomologous end joining [GO:0006303],
regulation of gene expression by genetic imprinting [GO:0006349],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
regulation of transcription from RNA polymerase III promoter [GO:0006359],
fatty acid biosynthetic process [GO:0006633],
apoptotic process [GO:0006915],
cellular response to DNA damage stimulus [GO:0006974],
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978],
chromosome segregation [GO:0007059],
centrosome cycle [GO:0007098],
intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630],
dosage compensation by inactivation of X chromosome [GO:0009048],
response to ionizing radiation [GO:0010212],
positive regulation of vascular endothelial growth factor production [GO:0010575],
positive regulation of gene expression [GO:0010628],
protein ubiquitination [GO:0016567],
protein deubiquitination [GO:0016579],
androgen receptor signaling pathway [GO:0030521],
positive regulation of protein ubiquitination [GO:0031398],
negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147],
positive regulation of histone acetylation [GO:0035066],
negative regulation of histone acetylation [GO:0035067],
regulation of cell proliferation [GO:0042127],
regulation of apoptotic process [GO:0042981],
chordate embryonic development [GO:0043009],
response to estrogen [GO:0043627],
regulation of DNA methylation [GO:0044030],
mitotic G2/M transition checkpoint [GO:0044818],
negative regulation of fatty acid biosynthetic process [GO:0045717],
positive regulation of DNA repair [GO:0045739],
positive regulation of angiogenesis [GO:0045766],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
negative regulation of centriole replication [GO:0046600],
positive regulation of histone H3-K4 methylation [GO:0051571],
negative regulation of histone H3-K4 methylation [GO:0051572],
negative regulation of histone H3-K9 methylation [GO:0051573],
positive regulation of histone H3-K9 methylation [GO:0051574],
protein autoubiquitination [GO:0051865],
negative regulation of G0 to G1 transition [GO:0070317],
positive regulation of histone H4-K20 methylation [GO:0070512],
positive regulation of cell cycle arrest [GO:0071158],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to indole-3-methanol [GO:0071681],
signal transduction involved in G2 DNA damage checkpoint [GO:0072425],
protein K6-linked ubiquitination [GO:0085020],
regulation of signal transduction by p53 class mediator [GO:1901796],
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042],
negative regulation of reactive oxygen species metabolic process [GO:2000378],
positive regulation of histone H3-K9 acetylation [GO:2000617],
positive regulation of histone H4-K16 acetylation [GO:2000620],
DNA repair [GO:0006281],
DNA recombination [GO:0006310],
lipid metabolic process [GO:0006629],
fatty acid metabolic process [GO:0006631],
cell cycle [GO:0007049],
centrosome duplication [GO:0051298],

Molecular Function:
DNA binding [GO:0003677],
damaged DNA binding [GO:0003684],
transcription coactivator activity [GO:0003713],
RNA binding [GO:0003723],
ubiquitin-protein transferase activity [GO:0004842],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
tubulin binding [GO:0015631],
enzyme binding [GO:0019899],
ubiquitin protein ligase binding [GO:0031625],
identical protein binding [GO:0042802],
transcription regulatory region DNA binding [GO:0044212],
androgen receptor binding [GO:0050681],
RNA polymerase binding [GO:0070063],
chromatin binding [GO:0003682],
transferase activity [GO:0016740],
metal ion binding [GO:0046872],

Cellular Component:
ubiquitin ligase complex [GO:0000151],
lateral element [GO:0000800],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
chromosome [GO:0005694],
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
gamma-tubulin ring complex [GO:0008274],
BRCA1-BARD1 complex [GO:0031436],
macromolecular complex [GO:0032991],
BRCA1-A complex [GO:0070531],
ribonucleoprotein complex [GO:1990904],
condensed chromosome [GO:0000793],
condensed nuclear chromosome [GO:0000794],
mitochondrial matrix [GO:0005759],
centrosome [GO:0005813],