TNFAIP3

TNF alpha induced protein 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
B-1 B cell homeostasis [GO:0001922],
response to molecule of bacterial origin [GO:0002237],
regulation of germinal center formation [GO:0002634],
negative regulation of chronic inflammatory response [GO:0002677],
apoptotic process [GO:0006915],
inflammatory response [GO:0006954],
cytoskeleton organization [GO:0007010],
regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803],
cell migration [GO:0016477],
protein deubiquitination [GO:0016579],
positive regulation of Wnt signaling pathway [GO:0030177],
negative regulation of protein ubiquitination [GO:0031397],
negative regulation of NF-kappaB transcription factor activity [GO:0032088],
negative regulation of type I interferon production [GO:0032480],
response to muramyl dipeptide [GO:0032495],
negative regulation of interleukin-2 production [GO:0032703],
negative regulation of interleukin-6 production [GO:0032715],
negative regulation of tumor necrosis factor production [GO:0032720],
negative regulation of toll-like receptor 2 signaling pathway [GO:0034136],
negative regulation of toll-like receptor 3 signaling pathway [GO:0034140],
negative regulation of toll-like receptor 4 signaling pathway [GO:0034144],
negative regulation of toll-like receptor 5 signaling pathway [GO:0034148],
protein K29-linked deubiquitination [GO:0035523],
protein K11-linked deubiquitination [GO:0035871],
negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124],
positive regulation of protein catabolic process [GO:0045732],
negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736],
negative regulation of bone resorption [GO:0045779],
negative regulation of innate immune response [GO:0045824],
negative regulation of smooth muscle cell proliferation [GO:0048662],
regulation of defense response to virus by host [GO:0050691],
negative regulation of interleukin-1 beta secretion [GO:0050713],
negative regulation of inflammatory response [GO:0050728],
negative regulation of B cell activation [GO:0050869],
protein oligomerization [GO:0051259],
regulation of vascular wound healing [GO:0061043],
cellular response to hydrogen peroxide [GO:0070301],
nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423],
negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070429],
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433],
protein K63-linked deubiquitination [GO:0070536],
protein K48-linked ubiquitination [GO:0070936],
protein K48-linked deubiquitination [GO:0071108],
cellular response to lipopolysaccharide [GO:0071222],
protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947],
tolerance induction to lipopolysaccharide [GO:0072573],
establishment of protein localization to vacuole [GO:0072666],
negative regulation of osteoclast proliferation [GO:0090291],
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042],
positive regulation of cellular protein catabolic process [GO:1903364],
protein K33-linked deubiquitination [GO:1990168],
positive regulation of hepatocyte proliferation [GO:2000347],
negative regulation of CD40 signaling pathway [GO:2000349],
negative regulation of endothelial cell apoptotic process [GO:2000352],
marginal zone B cell differentiation [GO:0002315],
negative regulation of granuloma formation [GO:0002632],
regulation of immunoglobulin production [GO:0002637],
proteolysis [GO:0006508],
metabolic process [GO:0008152],
response to wounding [GO:0009611],
negative regulation of autophagy [GO:0010507],
protein ubiquitination [GO:0016567],
negative regulation of interleukin-1 beta production [GO:0032691],
negative regulation of heterotypic cell-cell adhesion [GO:0034115],
regulation of innate immune response [GO:0045088],
negative regulation of cell death [GO:0060548],

Molecular Function:
protease binding [GO:0002020],
DNA binding [GO:0003677],
ubiquitin-protein transferase activity [GO:0004842],
thiol-dependent ubiquitin-specific protease activity [GO:0004843],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
kinase binding [GO:0019900],
thiol-dependent ubiquitinyl hydrolase activity [GO:0036459],
identical protein binding [GO:0042802],
ubiquitin binding [GO:0043130],
protein self-association [GO:0043621],
Lys63-specific deubiquitinase activity [GO:0061578],
K63-linked polyubiquitin binding [GO:0070530],
catalytic activity [GO:0003824],
peptidase activity [GO:0008233],
cysteine-type peptidase activity [GO:0008234],
transferase activity [GO:0016740],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
lysosome [GO:0005764],
cytosol [GO:0005829],
intracellular membrane-bounded organelle [GO:0043231],
extracellular exosome [GO:0070062],