BRAF

B-Raf proto-oncogene, serine/threonine kinase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
16079850 BJ, Phoenix-AMPHO Skin Human NO
17299132 Lung Mouse NO
17696195 Skin Human NO
18267069 BJ, primary melanocytes derived from skin Human NO
18650848 SK-MEL-28, Mel2a, FM88, NIH 3T3 Human NO
19345328 Skin Mouse NO
19389934 Primary melanocytes derived from skin Skin Human, mouse NO
20027224 COLO 32DM Human NO
20478260 Skin Human NO
20941790 Intestine Mouse NO
20959475 HEK 293T Human NO
21636552 Primary neurosphere cells derived from brain Human NO
22549727 TIG-3, HCA2, HEK 293T Human NO
24703243 TIG-3 Skin Human NO
24934810 Lung Mouse NO
25188864 Ovary Human NO
25499223 Primary cells derived from thymus Human, mouse NO
25673642 Skin Mouse NO
26028035 Lung Mouse NO
28745322 Lung Mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
23603840 SK-MEL-28, FM55M2 Human NO
29507566 Primary melanocytes derived from skin Human NO
29548335 Li Fraumeni Human YES
30159130 MM34, MM43, MM5, MM74, SK-MEL-28 Human, mouse NO

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
activation of MAPKK activity [GO:0000186],
myeloid progenitor cell differentiation [GO:0002318],
protein phosphorylation [GO:0006468],
visual learning [GO:0008542],
animal organ morphogenesis [GO:0009887],
positive regulation of gene expression [GO:0010628],
negative regulation of fibroblast migration [GO:0010764],
positive regulation of glucose transport [GO:0010828],
thyroid gland development [GO:0030878],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
somatic stem cell population maintenance [GO:0035019],
cellular response to drug [GO:0035690],
regulation of cell proliferation [GO:0042127],
negative regulation of apoptotic process [GO:0043066],
CD4-positive, alpha-beta T cell differentiation [GO:0043367],
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [GO:0043369],
response to peptide hormone [GO:0043434],
negative regulation of neuron apoptotic process [GO:0043524],
regulation of T cell differentiation [GO:0045580],
thymus development [GO:0048538],
positive regulation of axon regeneration [GO:0048680],
positive regulation of axonogenesis [GO:0050772],
T cell receptor signaling pathway [GO:0050852],
protein heterooligomerization [GO:0051291],
positive regulation of stress fiber assembly [GO:0051496],
response to cAMP [GO:0051591],
long-term synaptic potentiation [GO:0060291],
head morphogenesis [GO:0060323],
face development [GO:0060324],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
trehalose metabolism in response to stress [GO:0070413],
cellular response to calcium ion [GO:0071277],
establishment of protein localization to membrane [GO:0090150],
positive regulation of substrate adhesion-dependent cell spreading [GO:1900026],
cellular response to nerve growth factor stimulus [GO:1990090],
negative regulation of synaptic vesicle exocytosis [GO:2000301],
negative regulation of endothelial cell apoptotic process [GO:2000352],
signal transduction [GO:0007165],
phosphorylation [GO:0016310],
cell differentiation [GO:0030154],
intracellular signal transduction [GO:0035556],
positive T cell selection [GO:0043368],
alpha-beta T cell differentiation [GO:0046632],
regulation of axon regeneration [GO:0048679],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
MAP kinase kinase kinase activity [GO:0004709],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
ATP binding [GO:0005524],
small GTPase binding [GO:0031267],
mitogen-activated protein kinase kinase binding [GO:0031434],
identical protein binding [GO:0042802],
protein heterodimerization activity [GO:0046982],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
Ras GTPase binding [GO:0017016],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
mitochondrion [GO:0005739],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
neuron projection [GO:0043005],
intracellular membrane-bounded organelle [GO:0043231],
cell body [GO:0044297],
cytoplasm [GO:0005737],
membrane [GO:0016020],