BOK

BCL2 family apoptosis regulator BOK

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2, Li-Fraumeni Human YES
30987592 MCF7 Breast Human YES

GO terms:

Biological Process:
release of cytochrome c from mitochondria [GO:0001836],
apoptotic process [GO:0006915],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
cellular component disassembly involved in execution phase of apoptosis [GO:0006921],
brain development [GO:0007420],
cell proliferation [GO:0008283],
male gonad development [GO:0008584],
intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630],
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635],
regulation of autophagy [GO:0010506],
positive regulation of apoptotic process [GO:0043065],
negative regulation of neuron apoptotic process [GO:0043524],
oligodendrocyte differentiation [GO:0048709],
protein oligomerization [GO:0051259],
neuron apoptotic process [GO:0051402],
regulation of cytosolic calcium ion concentration [GO:0051480],
negative regulation of mitochondrial depolarization [GO:0051902],
negative regulation of necroptotic process [GO:0060546],
intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332],
extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192],
positive regulation of execution phase of apoptosis [GO:1900119],
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029],
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030],
regulation of chorionic trophoblast cell proliferation [GO:1901382],
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237],
positive regulation of PERK-mediated unfolded protein response [GO:1903899],
regulation of granulosa cell apoptotic process [GO:1904708],
positive regulation of intrinsic apoptotic signaling pathway [GO:2001244],
regulation of apoptotic process [GO:0042981],

Molecular Function:
receptor binding [GO:0005102],
protein binding [GO:0005515],
ubiquitin protein ligase binding [GO:0031625],
protein homodimerization activity [GO:0042803],
protein heterodimerization activity [GO:0046982],
BH domain binding [GO:0051400],
protein dimerization activity [GO:0046983],

Cellular Component:
nucleus [GO:0005634],
nuclear outer membrane [GO:0005640],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
mitochondrial outer membrane [GO:0005741],
mitochondrial inner membrane [GO:0005743],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
Golgi apparatus [GO:0005794],
integral component of membrane [GO:0016021],
early endosome membrane [GO:0031901],
mitochondrial membrane [GO:0031966],
trans-Golgi network membrane [GO:0032588],
cis-Golgi network membrane [GO:0033106],
recycling endosome membrane [GO:0055038],
endosome [GO:0005768],
membrane [GO:0016020],