biorientation of chromosomes in cell division 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA229 Skin, Lung Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
cell cycle [GO:0007049],
mitotic metaphase plate congression [GO:0007080],
negative regulation of phosphoprotein phosphatase activity [GO:0032515],
cell division [GO:0051301],
protein localization to chromosome, centromeric region [GO:0071459],
mitotic sister chromatid cohesion, centromeric [GO:0071962],
mitotic sister chromatid biorientation [GO:1990758],

Molecular Function:
protein phosphatase inhibitor activity [GO:0004864],
protein phosphatase 2A binding [GO:0051721],

Cellular Component:
chromosome, centromeric region [GO:0000775],
kinetochore [GO:0000776],
spindle pole [GO:0000922],
condensed chromosome outer kinetochore [GO:0000940],
chromosome [GO:0005694],
cytoplasm [GO:0005737],
centrosome [GO:0005813],
cytoskeleton [GO:0005856],
spindle microtubule [GO:0005876],