BMP7

bone morphogenetic protein 7

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
22124112 PC3, DU145, HS5, NIH 3T3, MRC-5, hFOB1.19, ALVA 41 Human NO
27696331 MCF7 Breast Human NO
29548335 Saos-2, Li-Fraumeni Human YES
30987592 MCF7 Breast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29367112 Primary cells derived from nucleous pulposus Rat NO
30787052 Primary cells derived from nucleous pulposus Human NO

GO terms:

Biological Process:
skeletal system development [GO:0001501],
ossification [GO:0001503],
metanephros development [GO:0001656],
ureteric bud development [GO:0001657],
mesoderm formation [GO:0001707],
mesonephros development [GO:0001823],
epithelial to mesenchymal transition [GO:0001837],
endocardial cushion formation [GO:0003272],
pericardium morphogenesis [GO:0003344],
axon guidance [GO:0007411],
embryonic pattern specification [GO:0009880],
regulation of receptor activity [GO:0010469],
positive regulation of gene expression [GO:0010628],
negative regulation of striated muscle cell apoptotic process [GO:0010664],
positive regulation of epithelial to mesenchymal transition [GO:0010718],
positive regulation of peptidyl-threonine phosphorylation [GO:0010800],
positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862],
dendrite development [GO:0016358],
neural fold elevation formation [GO:0021502],
embryonic limb morphogenesis [GO:0030326],
positive regulation of bone mineralization [GO:0030501],
BMP signaling pathway [GO:0030509],
epithelial cell differentiation [GO:0030855],
hindbrain development [GO:0030902],
negative regulation of NF-kappaB transcription factor activity [GO:0032088],
response to estradiol [GO:0032355],
response to vitamin D [GO:0033280],
positive regulation of heterotypic cell-cell adhesion [GO:0034116],
protein localization to nucleus [GO:0034504],
negative regulation of phosphorylation [GO:0042326],
odontogenesis of dentin-containing tooth [GO:0042475],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
steroid hormone mediated signaling pathway [GO:0043401],
negative regulation of MAP kinase activity [GO:0043407],
regulation of MAPK cascade [GO:0043408],
response to peptide hormone [GO:0043434],
negative regulation of neuron differentiation [GO:0045665],
positive regulation of osteoblast differentiation [GO:0045669],
negative regulation of Notch signaling pathway [GO:0045746],
negative regulation of cell cycle [GO:0045786],
negative regulation of mitotic nuclear division [GO:0045839],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
cell development [GO:0048468],
embryonic camera-type eye morphogenesis [GO:0048596],
cardiac muscle tissue development [GO:0048738],
branching morphogenesis of an epithelial tube [GO:0048754],
mesenchymal cell differentiation [GO:0048762],
neuron projection morphogenesis [GO:0048812],
cartilage development [GO:0051216],
pharyngeal system development [GO:0060037],
embryonic skeletal joint morphogenesis [GO:0060272],
regulation of pathway-restricted SMAD protein phosphorylation [GO:0060393],
SMAD protein signal transduction [GO:0060395],
cardiac septum morphogenesis [GO:0060411],
branching involved in salivary gland morphogenesis [GO:0060445],
mesenchyme development [GO:0060485],
negative regulation of cell death [GO:0060548],
negative regulation of prostatic bud formation [GO:0060686],
regulation of branching involved in prostate gland morphogenesis [GO:0060687],
chorio-allantoic fusion [GO:0060710],
heart trabecula morphogenesis [GO:0061384],
monocyte aggregation [GO:0070487],
cellular response to hypoxia [GO:0071456],
cellular response to BMP stimulus [GO:0071773],
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis [GO:0072040],
negative regulation of glomerular mesangial cell proliferation [GO:0072125],
metanephric mesenchyme morphogenesis [GO:0072133],
nephrogenic mesenchyme morphogenesis [GO:0072134],
metanephric mesenchymal cell proliferation involved in metanephros development [GO:0072136],
positive regulation of dendrite development [GO:1900006],
positive regulation of hyaluranon cable assembly [GO:1900106],
negative regulation of NIK/NF-kappaB signaling [GO:1901223],
allantois development [GO:1905069],
positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:1905312],
regulation of removal of superoxide radicals [GO:2000121],
eye development [GO:0001654],
kidney development [GO:0001822],
multicellular organism development [GO:0007275],
pattern specification process [GO:0007389],
salivary gland morphogenesis [GO:0007435],
negative regulation of cell proliferation [GO:0008285],
animal organ morphogenesis [GO:0009887],
positive regulation of cell death [GO:0010942],
cell differentiation [GO:0030154],
tube morphogenesis [GO:0035239],
regulation of phosphorylation [GO:0042325],
positive regulation of cell differentiation [GO:0045597],
positive regulation of neuron differentiation [GO:0045666],
camera-type eye morphogenesis [GO:0048593],
anatomical structure formation involved in morphogenesis [GO:0048646],
negative regulation of neurogenesis [GO:0050768],

Molecular Function:
cytokine activity [GO:0005125],
transforming growth factor beta receptor binding [GO:0005160],
protein binding [GO:0005515],
growth factor activity [GO:0008083],
heparin binding [GO:0008201],
BMP receptor binding [GO:0070700],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
vesicle [GO:0031982],