BMP4

bone morphogenetic protein 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
19158083 ARPE-19 Macular Human NO
19269967 NCI-H46, HCT 116, A549 Human NO
19269967 NCI-H46, A549 Lung Human NO
21050181 Primary cells derived from lung Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
18258400 HUVEC Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
activation of MAPKK activity [GO:0000186],
osteoblast differentiation [GO:0001649],
ureteric bud development [GO:0001657],
branching involved in ureteric bud morphogenesis [GO:0001658],
kidney development [GO:0001822],
mesonephros development [GO:0001823],
neural tube closure [GO:0001843],
positive regulation of protein phosphorylation [GO:0001934],
positive regulation of endothelial cell proliferation [GO:0001938],
endochondral ossification [GO:0001958],
blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043],
chondrocyte differentiation [GO:0002062],
hematopoietic progenitor cell differentiation [GO:0002244],
lymphoid progenitor cell differentiation [GO:0002320],
renal system process [GO:0003014],
BMP signaling pathway involved in heart induction [GO:0003130],
secondary heart field specification [GO:0003139],
outflow tract septum morphogenesis [GO:0003148],
membranous septum morphogenesis [GO:0003149],
muscular septum morphogenesis [GO:0003150],
aortic valve morphogenesis [GO:0003180],
pulmonary valve morphogenesis [GO:0003184],
endocardial cushion development [GO:0003197],
epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198],
cardiac right ventricle morphogenesis [GO:0003215],
apoptotic process involved in endocardial cushion morphogenesis [GO:0003277],
cardiac septum development [GO:0003279],
type B pancreatic cell development [GO:0003323],
mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337],
common-partner SMAD protein phosphorylation [GO:0007182],
smoothened signaling pathway [GO:0007224],
germ cell development [GO:0007281],
endoderm development [GO:0007492],
mesodermal cell fate determination [GO:0007500],
positive regulation of cell proliferation [GO:0008284],
negative regulation of cell proliferation [GO:0008285],
post-embryonic development [GO:0009791],
anterior/posterior axis specification [GO:0009948],
specification of animal organ position [GO:0010159],
regulation of cell fate commitment [GO:0010453],
regulation of receptor activity [GO:0010469],
positive regulation of endothelial cell migration [GO:0010595],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
positive regulation of epithelial to mesenchymal transition [GO:0010718],
positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862],
positive regulation of cell death [GO:0010942],
telencephalon development [GO:0021537],
dorsal/ventral neural tube patterning [GO:0021904],
telencephalon regionalization [GO:0021978],
pituitary gland development [GO:0021983],
erythrocyte differentiation [GO:0030218],
monocyte differentiation [GO:0030224],
macrophage differentiation [GO:0030225],
positive regulation of bone mineralization [GO:0030501],
BMP signaling pathway [GO:0030509],
positive regulation of BMP signaling pathway [GO:0030513],
positive regulation of protein binding [GO:0032092],
negative regulation of chondrocyte differentiation [GO:0032331],
positive regulation of collagen biosynthetic process [GO:0032967],
negative regulation of T cell differentiation in thymus [GO:0033085],
negative regulation of immature T cell proliferation in thymus [GO:0033088],
protein localization to nucleus [GO:0034504],
embryonic hindlimb morphogenesis [GO:0035116],
tendon cell differentiation [GO:0035990],
deltoid tuberosity development [GO:0035993],
regulation of protein import into nucleus [GO:0042306],
negative regulation of phosphorylation [GO:0042326],
odontogenesis of dentin-containing tooth [GO:0042475],
odontogenesis [GO:0042476],
regulation of odontogenesis of dentin-containing tooth [GO:0042487],
embryonic digit morphogenesis [GO:0042733],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
steroid hormone mediated signaling pathway [GO:0043401],
negative regulation of MAP kinase activity [GO:0043407],
regulation of MAPK cascade [GO:0043408],
post-translational protein modification [GO:0043687],
cellular protein metabolic process [GO:0044267],
positive regulation of endothelial cell differentiation [GO:0045603],
positive regulation of epidermal cell differentiation [GO:0045606],
negative regulation of myoblast differentiation [GO:0045662],
positive regulation of neuron differentiation [GO:0045666],
positive regulation of osteoblast differentiation [GO:0045669],
positive regulation of ossification [GO:0045778],
negative regulation of cell cycle [GO:0045786],
negative regulation of mitotic nuclear division [GO:0045839],
negative regulation of striated muscle tissue development [GO:0045843],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
lung alveolus development [GO:0048286],
intermediate mesodermal cell differentiation [GO:0048392],
cell development [GO:0048468],
positive regulation of smooth muscle cell proliferation [GO:0048661],
neuron fate commitment [GO:0048663],
embryonic cranial skeleton morphogenesis [GO:0048701],
smooth muscle tissue development [GO:0048745],
branching morphogenesis of an epithelial tube [GO:0048754],
positive regulation of epithelial cell proliferation [GO:0050679],
negative regulation of epithelial cell proliferation [GO:0050680],
positive chemotaxis [GO:0050918],
regulation of smooth muscle cell differentiation [GO:0051150],
cardiac muscle cell differentiation [GO:0055007],
positive regulation of cardiac muscle fiber development [GO:0055020],
inner ear receptor cell differentiation [GO:0060113],
cloacal septation [GO:0060197],
lens induction in camera-type eye [GO:0060235],
embryonic skeletal joint morphogenesis [GO:0060272],
cranial suture morphogenesis [GO:0060363],
positive regulation of SMAD protein import into nucleus [GO:0060391],
regulation of pathway-restricted SMAD protein phosphorylation [GO:0060393],
SMAD protein signal transduction [GO:0060395],
lung morphogenesis [GO:0060425],
bronchus development [GO:0060433],
trachea development [GO:0060438],
trachea formation [GO:0060440],
epithelial tube branching involved in lung morphogenesis [GO:0060441],
branching involved in prostate gland morphogenesis [GO:0060442],
bud elongation involved in lung branching [GO:0060449],
epithelial cell proliferation involved in lung morphogenesis [GO:0060502],
bud dilation involved in lung branching [GO:0060503],
negative regulation of cell death [GO:0060548],
mammary gland formation [GO:0060592],
epithelial-mesenchymal cell signaling [GO:0060684],
negative regulation of prostatic bud formation [GO:0060686],
regulation of branching involved in prostate gland morphogenesis [GO:0060687],
coronary vasculature development [GO:0060976],
positive regulation of cartilage development [GO:0061036],
positive regulation of branching involved in lung morphogenesis [GO:0061047],
BMP signaling pathway involved in ureter morphogenesis [GO:0061149],
BMP signaling pathway involved in renal system segmentation [GO:0061151],
pulmonary artery endothelial tube morphogenesis [GO:0061155],
BMP signaling pathway involved in heart development [GO:0061312],
pharyngeal arch artery morphogenesis [GO:0061626],
negative regulation of thymocyte apoptotic process [GO:0070244],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to BMP stimulus [GO:0071773],
BMP signaling pathway involved in nephric duct formation [GO:0071893],
renal system development [GO:0072001],
glomerular visceral epithelial cell development [GO:0072015],
negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway [GO:0072097],
specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway [GO:0072101],
glomerular capillary formation [GO:0072104],
negative regulation of glomerular mesangial cell proliferation [GO:0072125],
mesenchymal cell proliferation involved in ureteric bud development [GO:0072138],
mesenchymal cell differentiation involved in kidney development [GO:0072161],
ureter epithelial cell differentiation [GO:0072192],
ureter smooth muscle cell differentiation [GO:0072193],
mesenchymal cell proliferation involved in ureter development [GO:0072198],
negative regulation of mesenchymal cell proliferation involved in ureter development [GO:0072200],
metanephric collecting duct development [GO:0072205],
positive regulation of kidney development [GO:0090184],
negative regulation of branching involved in ureteric bud morphogenesis [GO:0090191],
negative regulation of glomerulus development [GO:0090194],
positive regulation of cell proliferation involved in outflow tract morphogenesis [GO:1901964],
regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902893],
negative regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902894],
positive regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903800],
cardiac jelly development [GO:1905072],
positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:1905312],
negative regulation of metanephric S-shaped body morphogenesis [GO:2000005],
negative regulation of metanephric comma-shaped body morphogenesis [GO:2000007],
negative regulation of cell proliferation involved in heart morphogenesis [GO:2000137],
negative regulation of extrinsic apoptotic signaling pathway [GO:2001237],
skeletal system development [GO:0001501],
ossification [GO:0001503],
angiogenesis [GO:0001525],
ovarian follicle development [GO:0001541],
blood vessel development [GO:0001568],
eye development [GO:0001654],
metanephros development [GO:0001656],
mesoderm formation [GO:0001707],
organ induction [GO:0001759],
regulation of endothelial cell proliferation [GO:0001936],
vasculature development [GO:0001944],
outflow tract morphogenesis [GO:0003151],
multicellular organism development [GO:0007275],
heart development [GO:0007507],
tissue development [GO:0009888],
regulation of gene expression [GO:0010468],
positive regulation of calcium ion transport into cytosol [GO:0010524],
positive regulation of neuron projection development [GO:0010976],
cell differentiation [GO:0030154],
lung development [GO:0030324],
embryonic limb morphogenesis [GO:0030326],
positive regulation of cell migration [GO:0030335],
forebrain development [GO:0030900],
positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949],
cellular response to oxidative stress [GO:0034599],
camera-type eye development [GO:0043010],
cell fate commitment [GO:0045165],
regulation of cell differentiation [GO:0045595],
positive regulation of cell differentiation [GO:0045597],
mesodermal cell differentiation [GO:0048333],
camera-type eye morphogenesis [GO:0048593],
embryonic morphogenesis [GO:0048598],
anatomical structure formation involved in morphogenesis [GO:0048646],
regulation of smooth muscle cell proliferation [GO:0048660],
embryonic skeletal system morphogenesis [GO:0048704],
embryonic skeletal system development [GO:0048706],
negative regulation of oligodendrocyte differentiation [GO:0048715],
smooth muscle cell differentiation [GO:0051145],
cartilage development [GO:0051216],
bone development [GO:0060348],
epithelium development [GO:0060429],
prostate gland morphogenesis [GO:0060512],
regulation of morphogenesis of a branching structure [GO:0060688],
regulation of cartilage development [GO:0061035],
positive regulation of hepatocyte differentiation [GO:0070368],
regulation of ERK1 and ERK2 cascade [GO:0070372],
cellular response to growth factor stimulus [GO:0071363],
cellular response to dexamethasone stimulus [GO:0071549],
positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190],
positive regulation of store-operated calcium channel activity [GO:1901341],
positive regulation of mesenchymal stem cell proliferation [GO:1902462],
positive regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902895],
positive regulation of endothelial cell apoptotic process [GO:2000353],
mesenchymal cell differentiation involved in renal system development [GO:2001012],

Molecular Function:
cytokine activity [GO:0005125],
transforming growth factor beta receptor binding [GO:0005160],
protein binding [GO:0005515],
growth factor activity [GO:0008083],
heparin binding [GO:0008201],
co-receptor binding [GO:0039706],
chemoattractant activity [GO:0042056],
BMP receptor binding [GO:0070700],
protein homodimerization activity [GO:0042803],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
endoplasmic reticulum lumen [GO:0005788],
cytoplasm [GO:0005737],
vesicle [GO:0031982],