BMP2

bone morphogenetic protein 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
22072987 IMR-90, MEF Human, mouse NO
24052948 Primary neural stem cells derived from brain Mouse NO
25406515 BJ, WI-38 Human NO
29548335 Saos-2, Li-Fraumeni Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
activation of MAPK activity [GO:0000187],
skeletal system development [GO:0001501],
osteoblast differentiation [GO:0001649],
branching involved in ureteric bud morphogenesis [GO:0001658],
response to hypoxia [GO:0001666],
in utero embryonic development [GO:0001701],
epithelial to mesenchymal transition [GO:0001837],
positive regulation of protein phosphorylation [GO:0001934],
positive regulation of endothelial cell proliferation [GO:0001938],
chondrocyte differentiation [GO:0002062],
BMP signaling pathway involved in heart induction [GO:0003130],
atrioventricular valve morphogenesis [GO:0003181],
endocardial cushion morphogenesis [GO:0003203],
negative regulation of Wnt signaling pathway involved in heart development [GO:0003308],
proteoglycan metabolic process [GO:0006029],
regulation of transcription, DNA-templated [GO:0006355],
protein phosphorylation [GO:0006468],
inflammatory response [GO:0006954],
Notch signaling pathway [GO:0007219],
cell-cell signaling [GO:0007267],
heart development [GO:0007507],
negative regulation of cell proliferation [GO:0008285],
response to bacterium [GO:0009617],
animal organ morphogenesis [GO:0009887],
regulation of receptor activity [GO:0010469],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
positive regulation of epithelial to mesenchymal transition [GO:0010718],
positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862],
negative regulation of steroid biosynthetic process [GO:0010894],
positive regulation of phosphatase activity [GO:0010922],
telencephalon development [GO:0021537],
telencephalon regionalization [GO:0021978],
positive regulation of Wnt signaling pathway [GO:0030177],
bone mineralization [GO:0030282],
positive regulation of cell migration [GO:0030335],
positive regulation of bone mineralization [GO:0030501],
BMP signaling pathway [GO:0030509],
protein destabilization [GO:0031648],
positive regulation of protein binding [GO:0032092],
negative regulation of aldosterone biosynthetic process [GO:0032348],
positive regulation of osteoblast proliferation [GO:0033690],
cardiocyte differentiation [GO:0035051],
embryonic heart tube anterior/posterior pattern specification [GO:0035054],
bone mineralization involved in bone maturation [GO:0035630],
odontogenesis of dentin-containing tooth [GO:0042475],
positive regulation of odontogenesis [GO:0042482],
regulation of odontogenesis of dentin-containing tooth [GO:0042487],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
regulation of MAPK cascade [GO:0043408],
positive regulation of MAPK cascade [GO:0043410],
negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569],
cell fate commitment [GO:0045165],
positive regulation of fat cell differentiation [GO:0045600],
positive regulation of neuron differentiation [GO:0045666],
positive regulation of osteoblast differentiation [GO:0045669],
positive regulation of ossification [GO:0045778],
negative regulation of cell cycle [GO:0045786],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
cell development [GO:0048468],
positive regulation of astrocyte differentiation [GO:0048711],
mesenchymal cell differentiation [GO:0048762],
inner ear development [GO:0048839],
negative regulation of calcium-independent cell-cell adhesion [GO:0051042],
cardiac muscle cell differentiation [GO:0055007],
cardiac muscle tissue morphogenesis [GO:0055008],
oxidation-reduction process [GO:0055114],
pericardium development [GO:0060039],
corticotropin hormone secreting cell differentiation [GO:0060128],
thyroid-stimulating hormone-secreting cell differentiation [GO:0060129],
cardiac epithelial to mesenchymal transition [GO:0060317],
pathway-restricted SMAD protein phosphorylation [GO:0060389],
SMAD protein signal transduction [GO:0060395],
mesenchyme development [GO:0060485],
positive regulation of Wnt signaling pathway by BMP signaling pathway [GO:0060804],
positive regulation of cartilage development [GO:0061036],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to organic cyclic compound [GO:0071407],
cellular response to BMP stimulus [GO:0071773],
mesenchymal cell proliferation involved in ureteric bud development [GO:0072138],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
positive regulation of p38MAPK cascade [GO:1900745],
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522],
positive regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902895],
negative regulation of cortisol biosynthetic process [GO:2000065],
negative regulation of cardiac muscle cell differentiation [GO:2000726],
ossification [GO:0001503],
transforming growth factor beta receptor signaling pathway [GO:0007179],
multicellular organism development [GO:0007275],
cell differentiation [GO:0030154],
positive regulation of cell differentiation [GO:0045597],
positive regulation of neurogenesis [GO:0050769],
cartilage development [GO:0051216],
cellular response to growth factor stimulus [GO:0071363],

Molecular Function:
retinol dehydrogenase activity [GO:0004745],
receptor binding [GO:0005102],
cytokine activity [GO:0005125],
transforming growth factor beta receptor binding [GO:0005160],
protein binding [GO:0005515],
growth factor activity [GO:0008083],
phosphatase activator activity [GO:0019211],
co-receptor binding [GO:0039706],
SMAD binding [GO:0046332],
protein heterodimerization activity [GO:0046982],
BMP receptor binding [GO:0070700],
protein domain specific binding [GO:0019904],
protein homodimerization activity [GO:0042803],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cell surface [GO:0009986],
intracellular membrane-bounded organelle [GO:0043231],
BMP receptor complex [GO:0070724],
cytoplasm [GO:0005737],
vesicle [GO:0031982],
macromolecular complex [GO:0032991],