BMI1

BMI1 proto-oncogene, polycomb ring finger

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
12482990 WI-38, 82-6, BJ Human NO
16936260 Primary cells derived from liver and bilary tree, mBECs Liver Human, mouse NO
17151361 WI-38, BJ, MRC-5, MCF1A, MCF7 Human NO
17233832 HMEC, HBEC, HDK, HDPC, HSAEC, HMSC, HPrEC Human NO
17344414 TIG-3, MEF Human, mouse NO
19695678 HuCCt1, TFK-1, HuH28, CCKS-1, TKKK, IGHKK, MEC, WI-38 Liver Human NO
20049504 MSCs Human NO
20170541 GES-1, MKN28, MKN45, KATOIII, NCI-N87, SUN-1, SGC-791, AGS, SUN-16 Gastric Human NO
20385206 Primary neural stem cells derived from brain Human NO
21368868 embryonic NSC Rat NO
21496667 DPSC, SCAP, NHK, NHF Human NO
22509111 HCECs Human NO
24915841 Kidney Mouse NO
25224681 Primary stem cells derived from adipose tissue Human NO
26238021 U‑87MG Human NO
26573462 MSCs, Primary cells derived from lung Umbilical vein , Lung Human, mouse NO
27009837 SGC-791, HGC-27 Human NO
27105531 MCF7, HEK 293T Human NO
27399693 SAS Human NO
27979861 HEK 293T, NHBE, CFBE Human NO
28410532 Primary stem cells derived from dental pulp Human NO
28593132 Brain Rat NO
28628915 HTR-8, HUVEC Umbilical cord Human NO
28790310 RIFs, HK2 Kidney Human, mouse NO
28968963 Primary epithelial cells derived from mammary gland Human NO
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
chromatin silencing [GO:0006342],
segment specification [GO:0007379],
regulation of gene expression [GO:0010468],
hemopoiesis [GO:0030097],
histone H2A-K119 monoubiquitination [GO:0036353],
negative regulation of gene expression, epigenetic [GO:0045814],
positive regulation of fibroblast proliferation [GO:0048146],
positive regulation of ubiquitin-protein transferase activity [GO:0051443],
negative regulation of G0 to G1 transition [GO:0070317],
skeletal system development [GO:0001501],
in utero embryonic development [GO:0001701],
DNA methylation [GO:0006306],
chromatin organization [GO:0006325],
humoral immune response [GO:0006959],
brain development [GO:0007420],
cellular process [GO:0009987],
histone acetylation [GO:0016573],
histone ubiquitination [GO:0016574],
rostrocaudal neural tube patterning [GO:0021903],
positive regulation of B cell proliferation [GO:0030890],
positive regulation of immature T cell proliferation in thymus [GO:0033092],
somatic stem cell division [GO:0048103],
embryonic skeletal system morphogenesis [GO:0048704],
embryonic skeletal system development [GO:0048706],
hematopoietic stem cell homeostasis [GO:0061484],
regulation of adaxial/abaxial pattern formation [GO:2000011],
negative regulation of apoptotic signaling pathway [GO:2001234],

Molecular Function:
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
RING-like zinc finger domain binding [GO:0071535],
promoter-specific chromatin binding [GO:1990841],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
chromatin binding [GO:0003682],
sequence-specific DNA binding [GO:0043565],
metal ion binding [GO:0046872],
ubiquitin-protein transferase activator activity [GO:0097027],

Cellular Component:
ubiquitin ligase complex [GO:0000151],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
nuclear body [GO:0016604],
PcG protein complex [GO:0031519],
PRC1 complex [GO:0035102],
heterochromatin [GO:0000792],
cytoplasm [GO:0005737],