BLM

BLM RecQ like helicase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
24832598 GM5565, GM969 Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
29449545 HMECs, MRC-5, IMR-90, GP293, WI-38, HUVEC Human NO
29548335 Saos-2, Li-Fraumeni Human YES

GO terms:

Biological Process:
regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079],
resolution of meiotic recombination intermediates [GO:0000712],
double-strand break repair via homologous recombination [GO:0000724],
DNA double-strand break processing [GO:0000729],
DNA synthesis involved in DNA repair [GO:0000731],
strand displacement [GO:0000732],
DNA strand renaturation [GO:0000733],
DNA replication [GO:0006260],
DNA repair [GO:0006281],
double-strand break repair via nonhomologous end joining [GO:0006303],
DNA recombination [GO:0006310],
cellular response to DNA damage stimulus [GO:0006974],
mitotic G2 DNA damage checkpoint [GO:0007095],
response to X-ray [GO:0010165],
meiotic DNA double-strand break processing involved in reciprocal meiotic recombination [GO:0010705],
replication fork processing [GO:0031297],
DNA duplex unwinding [GO:0032508],
negative regulation of apoptotic process [GO:0043066],
G-quadruplex DNA unwinding [GO:0044806],
double-strand break repair via synthesis-dependent strand annealing [GO:0045003],
positive regulation of transcription, DNA-templated [GO:0045893],
negative regulation of DNA recombination [GO:0045910],
negative regulation of mitotic recombination [GO:0045950],
alpha-beta T cell differentiation [GO:0046632],
positive regulation of alpha-beta T cell proliferation [GO:0046641],
replication fork protection [GO:0048478],
protein oligomerization [GO:0051259],
protein homooligomerization [GO:0051260],
meiotic chromosome separation [GO:0051307],
negative regulation of cell division [GO:0051782],
negative regulation of thymocyte apoptotic process [GO:0070244],
resolution of recombination intermediates [GO:0071139],
cellular response to ionizing radiation [GO:0071479],
cellular response to hydroxyurea [GO:0072711],
cellular response to camptothecin [GO:0072757],
regulation of DNA-dependent DNA replication [GO:0090329],
t-circle formation [GO:0090656],
negative regulation of double-strand break repair via single-strand annealing [GO:1901291],
regulation of signal transduction by p53 class mediator [GO:1901796],
positive regulation of double-strand break repair via homologous recombination [GO:1905168],
telomere maintenance [GO:0000723],
cellular response to drug [GO:0035690],
cellular metabolic process [GO:0044237],
regulation of binding [GO:0051098],
chromosome organization [GO:0051276],
replication-born double-strand break repair via sister chromatid exchange [GO:1990414],

Molecular Function:
four-way junction DNA binding [GO:0000400],
Y-form DNA binding [GO:0000403],
bubble DNA binding [GO:0000405],
p53 binding [GO:0002039],
DNA binding [GO:0003677],
DNA helicase activity [GO:0003678],
single-stranded DNA binding [GO:0003697],
ATP-dependent DNA helicase activity [GO:0004003],
helicase activity [GO:0004386],
protein binding [GO:0005515],
ATP binding [GO:0005524],
ATP-dependent helicase activity [GO:0008026],
DNA-dependent ATPase activity [GO:0008094],
zinc ion binding [GO:0008270],
four-way junction helicase activity [GO:0009378],
ATPase activity [GO:0016887],
annealing helicase activity [GO:0036310],
protein homodimerization activity [GO:0042803],
ATP-dependent 3'-5' DNA helicase activity [GO:0043140],
G-quadruplex DNA binding [GO:0051880],
forked DNA-dependent helicase activity [GO:0061749],
nucleotide binding [GO:0000166],
nucleic acid binding [GO:0003676],
catalytic activity [GO:0003824],
hydrolase activity [GO:0016787],
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818],
metal ion binding [GO:0046872],

Cellular Component:
nuclear chromosome [GO:0000228],
chromosome, telomeric region [GO:0000781],
lateral element [GO:0000800],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
replication fork [GO:0005657],
chromosome [GO:0005694],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
nuclear matrix [GO:0016363],
PML body [GO:0016605],
pronucleus [GO:0045120],
male germ cell nucleus [GO:0001673],