BIRC3

baculoviral IAP repeat containing 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
MyD88-independent toll-like receptor signaling pathway [GO:0002756],
apoptotic process [GO:0006915],
cell surface receptor signaling pathway [GO:0007166],
I-kappaB kinase/NF-kappaB signaling [GO:0007249],
spermatogenesis [GO:0007283],
regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803],
protein ubiquitination [GO:0016567],
protein deubiquitination [GO:0016579],
positive regulation of protein ubiquitination [GO:0031398],
tumor necrosis factor-mediated signaling pathway [GO:0033209],
regulation of toll-like receptor signaling pathway [GO:0034121],
TRIF-dependent toll-like receptor signaling pathway [GO:0035666],
NIK/NF-kappaB signaling [GO:0038061],
regulation of RIG-I signaling pathway [GO:0039535],
regulation of apoptotic process [GO:0042981],
negative regulation of apoptotic process [GO:0043066],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
regulation of innate immune response [GO:0045088],
regulation of inflammatory response [GO:0050727],
protein heterooligomerization [GO:0051291],
regulation of necroptotic process [GO:0060544],
negative regulation of necroptotic process [GO:0060546],
regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424],
inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001],
regulation of cysteine-type endopeptidase activity [GO:2000116],
negative regulation of phosphorylation [GO:0042326],
necroptotic process [GO:0070266],
cellular response to tumor necrosis factor [GO:0071356],
regulation of NIK/NF-kappaB signaling [GO:1901222],
positive regulation of protein polyubiquitination [GO:1902916],
negative regulation of reactive oxygen species metabolic process [GO:2000378],

Molecular Function:
ubiquitin-protein transferase activity [GO:0004842],
protein binding [GO:0005515],
transferase activity [GO:0016740],
cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027],
metal ion binding [GO:0046872],
ubiquitin protein ligase activity [GO:0061630],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
macromolecular complex [GO:0032991],
membrane raft [GO:0045121],