BIN1

bridging integrator 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30987592 MCF7 Breast Human YES

GO terms:

Biological Process:
endocytosis [GO:0006897],
nucleus organization [GO:0006997],
cytoskeleton organization [GO:0007010],
endosome to lysosome transport [GO:0008333],
viral process [GO:0016032],
regulation of endocytosis [GO:0030100],
positive regulation of actin filament polymerization [GO:0030838],
T-tubule organization [GO:0033292],
positive regulation of apoptotic process [GO:0043065],
regulation of neuron differentiation [GO:0045664],
positive regulation of astrocyte differentiation [GO:0048711],
nucleus localization [GO:0051647],
lipid tube assembly [GO:0060988],
membrane organization [GO:0061024],
regulation of cell cycle arrest [GO:0071156],
regulation of heart rate by cardiac conduction [GO:0086091],
negative regulation of potassium ion transmembrane transport [GO:1901380],
negative regulation of beta-amyloid formation [GO:1902430],
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902960],
negative regulation of ventricular cardiac muscle cell action potential [GO:1903946],
negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878],
multicellular organism development [GO:0007275],
cell differentiation [GO:0030154],
muscle cell differentiation [GO:0042692],
positive regulation of GTPase activity [GO:0043547],
positive regulation of endocytosis [GO:0045807],
synaptic vesicle endocytosis [GO:0048488],

Molecular Function:
protease binding [GO:0002020],
protein binding [GO:0005515],
phospholipid binding [GO:0005543],
clathrin binding [GO:0030276],
identical protein binding [GO:0042802],
tau protein binding [GO:0048156],
actin filament binding [GO:0051015],
chaperone binding [GO:0051087],
RNA polymerase binding [GO:0070063],
macromolecular complex binding [GO:0044877],
protein heterodimerization activity [GO:0046982],
GTPase binding [GO:0051020],

Cellular Component:
nucleus [GO:0005634],
nuclear envelope [GO:0005635],
cytoplasm [GO:0005737],
endosome [GO:0005768],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
synaptic vesicle [GO:0008021],
actin cytoskeleton [GO:0015629],
membrane [GO:0016020],
Z disc [GO:0030018],
T-tubule [GO:0030315],
axon [GO:0030424],
I band [GO:0031674],
node of Ranvier [GO:0033268],
axon initial segment [GO:0043194],
lipid tube [GO:0060987],
varicosity [GO:0043196],
axon terminus [GO:0043679],
cerebellar mossy fiber [GO:0044300],
synapse [GO:0045202],
extrinsic component of synaptic vesicle membrane [GO:0098850],
glutamatergic synapse [GO:0098978],