BIK

BCL2 interacting killer

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
30987592 MCF7 Breast Human YES

GO terms:

Biological Process:
apoptotic process [GO:0006915],
male gonad development [GO:0008584],
apoptotic mitochondrial changes [GO:0008637],
positive regulation of protein homooligomerization [GO:0032464],
positive regulation of release of cytochrome c from mitochondria [GO:0090200],
spermatogenesis [GO:0007283],

Molecular Function:
protein binding [GO:0005515],
protein heterodimerization activity [GO:0046982],
BH domain binding [GO:0051400],

Cellular Component:
endomembrane system [GO:0012505],
integral component of membrane [GO:0016021],
mitochondrial membrane [GO:0031966],
mitochondrion [GO:0005739],
mitochondrial envelope [GO:0005740],
membrane [GO:0016020],