BID

BH3 interacting domain death agonist

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
30987592 MCF7 Breast Human YES

GO terms:

Biological Process:
release of cytochrome c from mitochondria [GO:0001836],
protein targeting to mitochondrion [GO:0006626],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625],
apoptotic mitochondrial changes [GO:0008637],
positive regulation of mitochondrial membrane potential [GO:0010918],
positive regulation of protein oligomerization [GO:0032461],
positive regulation of protein homooligomerization [GO:0032464],
regulation of cell proliferation [GO:0042127],
signal transduction in response to DNA damage [GO:0042770],
mitochondrial ATP synthesis coupled electron transport [GO:0042775],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
protein homooligomerization [GO:0051260],
neuron apoptotic process [GO:0051402],
establishment of protein localization to membrane [GO:0090150],
positive regulation of release of cytochrome c from mitochondria [GO:0090200],
hepatocyte apoptotic process [GO:0097284],
mitochondrial outer membrane permeabilization [GO:0097345],
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740],
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030],
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230],
regulation of G1/S transition of mitotic cell cycle [GO:2000045],
positive regulation of fibroblast apoptotic process [GO:2000271],
positive regulation of extrinsic apoptotic signaling pathway [GO:2001238],
positive regulation of intrinsic apoptotic signaling pathway [GO:2001244],
apoptotic process [GO:0006915],
regulation of protein oligomerization [GO:0032459],
autophagy in response to ER overload [GO:0034263],
extrinsic apoptotic signaling pathway [GO:0097191],
regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108],
positive regulation of apoptotic signaling pathway [GO:2001235],

Molecular Function:
death receptor binding [GO:0005123],
protein binding [GO:0005515],
ubiquitin protein ligase binding [GO:0031625],
protein heterodimerization activity [GO:0046982],

Cellular Component:
mitochondrion [GO:0005739],
mitochondrial outer membrane [GO:0005741],
cytosol [GO:0005829],
membrane [GO:0016020],
integral component of mitochondrial membrane [GO:0032592],
cytoplasm [GO:0005737],