ACE

angiotensin I converting enzyme

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

GO terms:

Biological Process:
kidney development [GO:0001822],
blood vessel remodeling [GO:0001974],
angiotensin maturation [GO:0002003],
regulation of renal output by angiotensin [GO:0002019],
neutrophil mediated immunity [GO:0002446],
antigen processing and presentation of peptide antigen via MHC class I [GO:0002474],
regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081],
positive regulation of systemic arterial blood pressure [GO:0003084],
proteolysis [GO:0006508],
spermatogenesis [GO:0007283],
regulation of blood pressure [GO:0008217],
posttranscriptional regulation of gene expression [GO:0010608],
negative regulation of gene expression [GO:0010629],
regulation of smooth muscle cell migration [GO:0014910],
regulation of vasoconstriction [GO:0019229],
negative regulation of protein binding [GO:0032091],
positive regulation of protein binding [GO:0032092],
mononuclear cell proliferation [GO:0032943],
hormone catabolic process [GO:0042447],
peptide catabolic process [GO:0043171],
positive regulation of blood pressure [GO:0045777],
beta-amyloid metabolic process [GO:0050435],
arachidonic acid secretion [GO:0050482],
heart contraction [GO:0060047],
regulation of angiotensin metabolic process [GO:0060177],
hematopoietic stem cell differentiation [GO:0060218],
positive regulation of protein tyrosine kinase activity [GO:0061098],
cell proliferation in bone marrow [GO:0071838],
positive regulation of peptidyl-tyrosine autophosphorylation [GO:1900086],
regulation of hematopoietic stem cell proliferation [GO:1902033],
negative regulation of gap junction assembly [GO:1903597],
positive regulation of peptidyl-cysteine S-nitrosylation [GO:2000170],
peptide metabolic process [GO:0006518],
embryo development ending in birth or egg hatching [GO:0009792],
bradykinin catabolic process [GO:0010815],
sensory perception of pain [GO:0019233],
animal organ regeneration [GO:0031100],
response to lipopolysaccharide [GO:0032496],
negative regulation of renal sodium excretion [GO:0035814],
vasoconstriction [GO:0042310],
eating behavior [GO:0042755],
positive regulation of apoptotic process [GO:0043065],
negative regulation of glucose import [GO:0046325],
lung alveolus development [GO:0048286],
positive regulation of inflammatory response [GO:0050729],
positive regulation of neurogenesis [GO:0050769],
angiogenesis involved in coronary vascular morphogenesis [GO:0060978],
negative regulation of calcium ion import [GO:0090281],

Molecular Function:
endopeptidase activity [GO:0004175],
carboxypeptidase activity [GO:0004180],
drug binding [GO:0008144],
metallopeptidase activity [GO:0008237],
exopeptidase activity [GO:0008238],
dipeptidyl-peptidase activity [GO:0008239],
tripeptidyl-peptidase activity [GO:0008240],
peptidyl-dipeptidase activity [GO:0008241],
zinc ion binding [GO:0008270],
chloride ion binding [GO:0031404],
mitogen-activated protein kinase kinase binding [GO:0031434],
bradykinin receptor binding [GO:0031711],
mitogen-activated protein kinase binding [GO:0051019],
metallodipeptidase activity [GO:0070573],
actin binding [GO:0003779],
protein binding [GO:0005515],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
lysosome [GO:0005764],
endosome [GO:0005768],
plasma membrane [GO:0005886],
external side of plasma membrane [GO:0009897],
integral component of membrane [GO:0016021],
extracellular exosome [GO:0070062],
cytoplasm [GO:0005737],
basal plasma membrane [GO:0009925],
membrane [GO:0016020],
brush border membrane [GO:0031526],
vesicle [GO:0031982],
sperm midpiece [GO:0097225],