basic helix-loop-helix family member e41

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
somitogenesis [GO:0001756],
regulation of transcription, DNA-templated [GO:0006355],
Notch signaling pathway [GO:0007219],
circadian rhythm [GO:0007623],
negative regulation of myotube differentiation [GO:0010832],
negative regulation of transcription by competitive promoter binding [GO:0010944],
cell differentiation [GO:0030154],
circadian regulation of gene expression [GO:0032922],
negative regulation of transcription, DNA-templated [GO:0045892],
rhythmic process [GO:0048511],
regulation of neurogenesis [GO:0050767],
cell proliferation [GO:0008283],
animal organ morphogenesis [GO:0009887],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II distal enhancer sequence-specific DNA binding [GO:0000980],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
RNA polymerase II activating transcription factor binding [GO:0001102],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
DNA binding [GO:0003677],
transcription corepressor activity [GO:0003714],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
protein homodimerization activity [GO:0042803],
histone deacetylase binding [GO:0042826],
bHLH transcription factor binding [GO:0043425],
MRF binding [GO:0043426],
sequence-specific DNA binding [GO:0043565],
protein heterodimerization activity [GO:0046982],
protein dimerization activity [GO:0046983],
E-box binding [GO:0070888],
N-box binding [GO:0071820],
sequence-specific double-stranded DNA binding [GO:1990837],

Cellular Component:
nucleus [GO:0005634],
transcriptional repressor complex [GO:0017053],