BHLHE40

basic helix-loop-helix family member e40

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
16079833 IMR-90 Lung, skin, pancreas Mouse NO
18025081 MCF7, U-2 OS Human NO
22844531 EC9706 Esophagus Human NO
30987592 MCF7 Breast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
somitogenesis [GO:0001756],
regulation of transcription, DNA-templated [GO:0006355],
Notch signaling pathway [GO:0007219],
circadian rhythm [GO:0007623],
cell differentiation [GO:0030154],
circadian regulation of gene expression [GO:0032922],
regulation of circadian rhythm [GO:0042752],
entrainment of circadian clock by photoperiod [GO:0043153],
negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433],
negative regulation of transcription, DNA-templated [GO:0045892],
regulation of neurogenesis [GO:0050767],
response to light stimulus [GO:0009416],
rhythmic process [GO:0048511],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II distal enhancer sequence-specific DNA binding [GO:0000980],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
RNA polymerase II activating transcription factor binding [GO:0001102],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
transcription corepressor activity [GO:0003714],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
protein domain specific binding [GO:0019904],
protein homodimerization activity [GO:0042803],
bHLH transcription factor binding [GO:0043425],
MRF binding [GO:0043426],
sequence-specific DNA binding [GO:0043565],
protein heterodimerization activity [GO:0046982],
E-box binding [GO:0070888],
sequence-specific double-stranded DNA binding [GO:1990837],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
DNA binding [GO:0003677],
protein dimerization activity [GO:0046983],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
nuclear body [GO:0016604],