BGLAP

bone gamma-carboxyglutamate protein

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30696833 Primary cells deived from vascular smooth muscle Human NO

GO terms:

Biological Process:
skeletal system development [GO:0001501],
ossification [GO:0001503],
osteoblast differentiation [GO:0001649],
osteoblast development [GO:0002076],
ER to Golgi vesicle-mediated transport [GO:0006888],
cell adhesion [GO:0007155],
cell aging [GO:0007569],
response to mechanical stimulus [GO:0009612],
response to gravity [GO:0009629],
response to zinc ion [GO:0010043],
response to activity [GO:0014823],
bone mineralization [GO:0030282],
regulation of bone mineralization [GO:0030500],
response to vitamin K [GO:0032571],
response to vitamin D [GO:0033280],
response to testosterone [GO:0033574],
response to hydroxyisoflavone [GO:0033594],
odontogenesis [GO:0042476],
response to estrogen [GO:0043627],
regulation of bone resorption [GO:0045124],
response to ethanol [GO:0045471],
regulation of osteoclast differentiation [GO:0045670],
response to glucocorticoid [GO:0051384],
bone development [GO:0060348],
cellular response to vitamin D [GO:0071305],
cellular response to growth factor stimulus [GO:0071363],
regulation of cellular response to insulin stimulus [GO:1900076],
biomineral tissue development [GO:0031214],
cellular response to BMP stimulus [GO:0071773],

Molecular Function:
structural molecule activity [GO:0005198],
calcium ion binding [GO:0005509],
structural constituent of bone [GO:0008147],
hydroxyapatite binding [GO:0046848],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
endoplasmic reticulum lumen [GO:0005788],
rough endoplasmic reticulum [GO:0005791],
Golgi lumen [GO:0005796],
dendrite [GO:0030425],
vesicle [GO:0031982],
perikaryon [GO:0043204],
Golgi apparatus [GO:0005794],
cell projection [GO:0042995],