ACD

ACD shelterin complex subunit and telomerase recruitment factor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
telomere maintenance [GO:0000723],
skeletal system development [GO:0001501],
urogenital system development [GO:0001655],
intracellular protein transport [GO:0006886],
telomere capping [GO:0016233],
embryonic limb morphogenesis [GO:0030326],
protection from non-homologous end joining at telomere [GO:0031848],
telomere assembly [GO:0032202],
negative regulation of telomere maintenance via telomerase [GO:0032211],
positive regulation of telomere maintenance via telomerase [GO:0032212],
segmentation [GO:0035282],
positive regulation of telomerase activity [GO:0051973],
positive regulation of single-stranded telomeric DNA binding [GO:0060381],
protein localization to chromosome, telomeric region [GO:0070198],
establishment of protein localization to telomere [GO:0070200],
mitotic telomere maintenance via semi-conservative replication [GO:1902990],
telomere-telomerase complex assembly [GO:1905324],

Molecular Function:
protein binding [GO:0005515],
telomeric DNA binding [GO:0042162],
macromolecular complex binding [GO:0044877],
DNA polymerase binding [GO:0070182],
protein binding involved in negative regulation of telomere maintenance via telomerase [GO:1902496],
DNA binding [GO:0003677],

Cellular Component:
nuclear telomere cap complex [GO:0000783],
nuclear chromosome, telomeric region [GO:0000784],
nucleoplasm [GO:0005654],
nuclear body [GO:0016604],
telosome [GO:0070187],
chromosome, telomeric region [GO:0000781],
nucleus [GO:0005634],
chromosome [GO:0005694],