beclin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21678067 C85 Human NO
27462784 T-47-D, MCF7 Human NO
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29991800 U87 Human NO
30807795 HT-22 Mouse NO

GO terms:

Biological Process:
autophagosome assembly [GO:0000045],
mitophagy [GO:0000422],
macromitophagy [GO:0000423],
response to hypoxia [GO:0001666],
autophagy [GO:0006914],
apoptotic process [GO:0006915],
cellular defense response [GO:0006968],
cellular response to nitrogen starvation [GO:0006995],
lysosome organization [GO:0007040],
mitotic metaphase plate congression [GO:0007080],
aging [GO:0007568],
negative regulation of cell proliferation [GO:0008285],
response to iron(II) ion [GO:0010040],
response to lead ion [GO:0010288],
positive regulation of cardiac muscle hypertrophy [GO:0010613],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
viral process [GO:0016032],
macroautophagy [GO:0016236],
protein deubiquitination [GO:0016579],
CVT pathway [GO:0032258],
regulation of cytokinesis [GO:0032465],
receptor catabolic process [GO:0032801],
response to vitamin E [GO:0033197],
cellular response to amino acid starvation [GO:0034198],
cellular response to glucose starvation [GO:0042149],
negative regulation of apoptotic process [GO:0043066],
engulfment of apoptotic cell [GO:0043652],
early endosome to late endosome transport [GO:0045022],
late endosome to vacuole transport [GO:0045324],
neuron development [GO:0048666],
beta-amyloid metabolic process [GO:0050435],
regulation of catalytic activity [GO:0050790],
cell division [GO:0051301],
defense response to virus [GO:0051607],
negative regulation of cell death [GO:0060548],
cellular response to hydrogen peroxide [GO:0070301],
cellular response to aluminum ion [GO:0071275],
cellular response to copper ion [GO:0071280],
cellular response to epidermal growth factor stimulus [GO:0071364],
response to mitochondrial depolarisation [GO:0098780],
positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425],
negative regulation of autophagosome assembly [GO:1902902],
negative regulation of reactive oxygen species metabolic process [GO:2000378],
positive regulation of autophagosome assembly [GO:2000786],
positive regulation of intrinsic apoptotic signaling pathway [GO:2001244],
angiogenesis [GO:0001525],
endocytosis [GO:0006897],
cell cycle [GO:0007049],
negative regulation of autophagy [GO:0010507],
positive regulation of autophagy [GO:0010508],
response to other organism [GO:0051707],

Molecular Function:
protein binding [GO:0005515],
protein kinase binding [GO:0019901],
ubiquitin protein ligase binding [GO:0031625],
protein homodimerization activity [GO:0042803],
phosphatidylinositol 3-kinase binding [GO:0043548],
GTPase binding [GO:0051020],

Cellular Component:
pre-autophagosomal structure [GO:0000407],
nucleus [GO:0005634],
mitochondrion [GO:0005739],
endosome [GO:0005768],
autophagosome [GO:0005776],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
trans-Golgi network [GO:0005802],
cytosol [GO:0005829],
endosome membrane [GO:0010008],
extrinsic component of membrane [GO:0019898],
dendrite [GO:0030425],
mitochondrial membrane [GO:0031966],
phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271],
phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272],
phosphatidylinositol 3-kinase complex, class III [GO:0035032],
phagocytic vesicle [GO:0045335],
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
cytoskeleton [GO:0005856],
membrane [GO:0016020],
cytoplasmic vesicle [GO:0031410],
macromolecular complex [GO:0032991],