BCL6

BCL6 transcription repressor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2, Li-Fraumeni Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
11914273 MEF, primary T- cells derived from tonsil Human, mouse NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
cell morphogenesis [GO:0000902],
negative regulation of cell-matrix adhesion [GO:0001953],
germinal center formation [GO:0002467],
regulation of germinal center formation [GO:0002634],
negative regulation of B cell apoptotic process [GO:0002903],
inflammatory response [GO:0006954],
cellular response to DNA damage stimulus [GO:0006974],
Rho protein signal transduction [GO:0007266],
spermatogenesis [GO:0007283],
protein localization [GO:0008104],
negative regulation of cell proliferation [GO:0008285],
cytokine-mediated signaling pathway [GO:0019221],
actin cytoskeleton organization [GO:0030036],
B cell differentiation [GO:0030183],
negative regulation of cell growth [GO:0030308],
positive regulation of B cell proliferation [GO:0030890],
positive regulation of histone deacetylation [GO:0031065],
negative regulation of mast cell cytokine production [GO:0032764],
negative regulation of Rho protein signal transduction [GO:0035024],
type 2 immune response [GO:0042092],
regulation of cell proliferation [GO:0042127],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
regulation of GTPase activity [GO:0043087],
regulation of memory T cell differentiation [GO:0043380],
positive regulation of regulatory T cell differentiation [GO:0045591],
negative regulation of T-helper 2 cell differentiation [GO:0045629],
positive regulation of neuron differentiation [GO:0045666],
negative regulation of Notch signaling pathway [GO:0045746],
negative regulation of transcription, DNA-templated [GO:0045892],
negative regulation of isotype switching to IgE isotypes [GO:0048294],
erythrocyte development [GO:0048821],
regulation of inflammatory response [GO:0050727],
regulation of immune response [GO:0050776],
positive regulation of cellular component movement [GO:0051272],
negative regulation of mitotic cell cycle DNA replication [GO:1903464],
negative regulation of cellular senescence [GO:2000773],
immune system process [GO:0002376],
negative regulation of type 2 immune response [GO:0002829],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
negative regulation of apoptotic process [GO:0043066],
negative regulation of cell differentiation [GO:0045596],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
intronic transcription regulatory region sequence-specific DNA binding [GO:0001161],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
chromatin DNA binding [GO:0031490],
identical protein binding [GO:0042802],
sequence-specific DNA binding [GO:0043565],
metal ion binding [GO:0046872],
nucleic acid binding [GO:0003676],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
replication fork [GO:0005657],
Golgi apparatus [GO:0005794],