BCL3 transcription coactivator

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
follicular dendritic cell differentiation [GO:0002268],
marginal zone B cell differentiation [GO:0002315],
humoral immune response mediated by circulating immunoglobulin [GO:0002455],
germinal center formation [GO:0002467],
transcription, DNA-templated [GO:0006351],
cellular response to DNA damage stimulus [GO:0006974],
I-kappaB kinase/NF-kappaB signaling [GO:0007249],
response to virus [GO:0009615],
response to UV-C [GO:0010225],
antimicrobial humoral response [GO:0019730],
extracellular matrix organization [GO:0030198],
DNA damage response, signal transduction by p53 class mediator [GO:0030330],
positive regulation of interferon-gamma production [GO:0032729],
T-helper 1 type immune response [GO:0042088],
negative regulation of tumor necrosis factor biosynthetic process [GO:0042536],
defense response to bacterium [GO:0042742],
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771],
defense response to protozoan [GO:0042832],
regulation of apoptotic process [GO:0042981],
negative regulation of apoptotic process [GO:0043066],
T-helper 2 cell differentiation [GO:0045064],
positive regulation of interleukin-10 biosynthetic process [GO:0045082],
negative regulation of interleukin-8 biosynthetic process [GO:0045415],
positive regulation of translation [GO:0045727],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
negative regulation of JAK-STAT cascade [GO:0046426],
spleen development [GO:0048536],
regulation of DNA binding [GO:0051101],
maintenance of protein location in nucleus [GO:0051457],
regulation of NIK/NF-kappaB signaling [GO:1901222],

Molecular Function:
DNA binding [GO:0003677],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
protein binding, bridging [GO:0030674],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
midbody [GO:0030496],
macromolecular complex [GO:0032991],
Bcl3-Bcl10 complex [GO:0032996],
Bcl3/NF-kappaB2 complex [GO:0033257],
intracellular membrane-bounded organelle [GO:0043231],
perinuclear region of cytoplasm [GO:0048471],