BCL2L1

BCL2 like 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21678067 C-85 Human NO
24050266 U2OS Human NO
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
30482844 MDA-MB-231, HCC38, BT549, HCC1143, HCC7, MDA-MB-468 Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
14764594 EJ Human NO
21292770 HT-29, LS 174T Human NO
24055032 CNE-2 Human NO
27398719 BJ Human NO
27794564 MEF, Primary lymphocytes cells derived from blood Human, mouse NO
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
ovarian follicle development [GO:0001541],
in utero embryonic development [GO:0001701],
release of cytochrome c from mitochondria [GO:0001836],
endocytosis [GO:0006897],
mitotic cell cycle checkpoint [GO:0007093],
germ cell development [GO:0007281],
spermatogenesis [GO:0007283],
cell proliferation [GO:0008283],
positive regulation of cell proliferation [GO:0008284],
male gonad development [GO:0008584],
intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630],
apoptotic mitochondrial changes [GO:0008637],
fertilization [GO:0009566],
suppression by virus of host apoptotic process [GO:0019050],
cytokine-mediated signaling pathway [GO:0019221],
regulation of cytokinesis [GO:0032465],
response to cytokine [GO:0034097],
regulation of growth [GO:0040008],
negative regulation of apoptotic process [GO:0043066],
negative regulation of neuron apoptotic process [GO:0043524],
response to cycloheximide [GO:0046898],
regulation of mitochondrial membrane permeability [GO:0046902],
neuron apoptotic process [GO:0051402],
regulation of mitochondrial membrane potential [GO:0051881],
cellular process regulating host cell cycle in response to virus [GO:0060154],
mitochondrion morphogenesis [GO:0070584],
cellular response to amino acid stimulus [GO:0071230],
cellular response to alkaloid [GO:0071312],
cellular response to gamma radiation [GO:0071480],
apoptotic process in bone marrow [GO:0071839],
negative regulation of release of cytochrome c from mitochondria [GO:0090201],
extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192],
hepatocyte apoptotic process [GO:0097284],
negative regulation of execution phase of apoptosis [GO:1900118],
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042],
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230],
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236],
negative regulation of protein localization to plasma membrane [GO:1903077],
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240],
negative regulation of intrinsic apoptotic signaling pathway [GO:2001243],
positive regulation of intrinsic apoptotic signaling pathway [GO:2001244],
response to ischemia [GO:0002931],
apoptotic process [GO:0006915],
response to radiation [GO:0009314],
response to virus [GO:0009615],
synaptic vesicle recycling via endosome [GO:0036466],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
positive regulation of synaptic vesicle endocytosis [GO:1900244],
regulation of long term synaptic depression [GO:1900452],
positive regulation of synaptic vesicle exocytosis [GO:2000302],
positive regulation of synaptic vesicle clustering [GO:2000809],
negative regulation of anoikis [GO:2000811],
positive regulation of ATP biosynthetic process [GO:2001171],

Molecular Function:
protein binding [GO:0005515],
protein kinase binding [GO:0019901],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
protein heterodimerization activity [GO:0046982],
BH3 domain binding [GO:0051434],
transcription factor binding [GO:0008134],
clathrin binding [GO:0030276],
cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027],
macromolecular complex binding [GO:0044877],
GTPase binding [GO:0051020],
BH domain binding [GO:0051400],
MDM2/MDM4 family protein binding [GO:0097371],

Cellular Component:
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
mitochondrial outer membrane [GO:0005741],
mitochondrial inner membrane [GO:0005743],
mitochondrial matrix [GO:0005759],
endoplasmic reticulum [GO:0005783],
centrosome [GO:0005813],
cytosol [GO:0005829],
integral component of membrane [GO:0016021],
cell junction [GO:0030054],
synaptic vesicle membrane [GO:0030672],
nuclear membrane [GO:0031965],
Bcl-2 family protein complex [GO:0097136],
nucleus [GO:0005634],
mitochondrial envelope [GO:0005740],
cytoskeleton [GO:0005856],
clathrin-coated pit [GO:0005905],
membrane [GO:0016020],
cytoplasmic vesicle [GO:0031410],
mitochondrial membrane [GO:0031966],
synapse [GO:0045202],
presynapse [GO:0098793],